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Noradrenergic

Drugs related to noradrenergic transmission

QuestionAnswerEffectIndicaties
α1-selectieve agonisten Tramazoline Oxymetazoline Fenylefrine VC via α1 receptoren Lokaal: decongestie van nasale muceuze membranen
α2-selectieve agonisten Clonidine Daling BP, stimu van autoregulerende α2receptoren in hersenstam met daling van OSy impulsen nr periferie. Stimu van presynaptische α2recept op postggl OSy kan ook bijdrage leveren Hypertensie Profylaxe v. migraine
ß-agonisten Isoprenaline(zowel ß1 en ß2) Dobutamine(vnl ß1) Isoprenaline: + ino- en chronotroop effect + daling perif R Dobutamine: +ino en chronotroop effect met minder invloed op perif R Isoprenaline: in Afwacht van implantatie vn pacemaker bij bradycardie Dobutamine: Schocktoestanden
ß2-selectieve agonisten Terbutaline(kort) Salbutamol(kort) Salmeterol(lang) Formoterol(lang) Ritodrine Bronchodilatie en relax van de uterus via ß2 stimulatie Asthma Bronchiale(inhalatie) Inhibitie vn premature arbeid
Antagonisten v Adrenoreceptoren Fentolamine Block vn zowel α1 α2 VD en -BP. Daling vn BP leidt tot verhoogde OS impulsen via baroreceptoren. Door meer noradrenaline : tachycardie(ß1) Auto-inhibitie thv v perif OSy is geremd door block presynaptische α2 Feochromocytoom: in afwacht v operatie en tijdens operatie voor de hypertensieve periodes.
α1- selectieve antagonisten Prazosine Terazosine Alfuzosine Tamsulosine Daling BP met minder reflexe tachycardie(geen blok v α2) Bevordering v mictie bij benigne prostaathypertrofie Hypertensie(prazosine en terazosine) Fenomeen van Raynaud(prazosine) Benigne prostaathypertrofie(terazosine, alfuzosine, tamsulosine)
α2-selectieve antagonisten Yohimbine Impotentie
ß-Antagonisten zie tabel: p BF.NOR 10 Daling: HF, mycardcontractiliteit, myocardiale O2 consumptie. Geleidelijke daling BP over meerdere dagen bij hypertensie. Plus extra: BF.NOR 11 CVS: Hypertensie, Angina pectoris, supraventriculaire hartaritmieën, na Myocardinfarct) Hartfalen Preventie v slokdarmvarices bij portale hypertensie Andere: glaucoom, thyreotoxicose, idiopatisch beven, preventie v migraine
Agonisten van Adrenoreceptoren Noradrenaline Adrenaline IV noradrenaline: >BP via α1-receptoren IV adrenaline: <periR via ß2 in bloedvaten vn skeletspieren, terwijl >HF via cardiale ß1recept. BP blijft gelijk tenzij bij snelle IV inj van adrenaline.(via α1 en stijging vn Afterload) Schocktoestanden: Adrenaline Combo met lokale anesthetica ter preventie van resorptie
Created by: 833554593
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