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Drug Met phases
Phases of Drug Metabolism
Question | Answer |
---|---|
oxidation | phase 1 (functionalization) |
reduction | phase 1 (functionalization) |
hydrolysis | phase 1 (functionalization) |
glucuronide conjugation (glucuronadation) | phase 2 (conjugation) |
sulfate conjugation (sulfation) | phase 2 (conjugation) |
methylation | phase 2 (conjugation) |
acetylation | phase 2 (conjugation) |
peptide (glycine) conjugation | phase 2 (conjugation) |
gluthione conjugation | phase 2 (conjugation) |
which reaction is most important in humans? | glucuronide conjugation (glucuronadation) |
cytochrome p450 | phase 1 enzyme |
non cyp enzymes (e.g. alcohol dehydogenase, xanthine oxide) | phase 1 enzyme |
UDP glucuronosyl transferase | phase 2 enzyme |
sulfotransferase | phase 2 enzyme |
methyl transferase | phase 2 enzyme |
acetyl transferase | phase 2 enzyme |
Acyl CoA: glycine N-acyl transferase | phase 2 enzyme |
gluthathione s-transferase | phase 2 enzyme |
aromatic hydroxylation | phase 1 pathway |
aliphatic hydroxylation | phase 1 pathway |
oxidative N-dealkylation | phase 1 pathway |
oxidative O-dealkylation | phase 1 pathway |
S-oxidation | phase 1 pathway |
reduction | phase 1 pathway |
hydrolysis | phase 1 pathway |