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Drug Met phases
Phases of Drug Metabolism
| Question | Answer |
|---|---|
| oxidation | phase 1 (functionalization) |
| reduction | phase 1 (functionalization) |
| hydrolysis | phase 1 (functionalization) |
| glucuronide conjugation (glucuronadation) | phase 2 (conjugation) |
| sulfate conjugation (sulfation) | phase 2 (conjugation) |
| methylation | phase 2 (conjugation) |
| acetylation | phase 2 (conjugation) |
| peptide (glycine) conjugation | phase 2 (conjugation) |
| gluthione conjugation | phase 2 (conjugation) |
| which reaction is most important in humans? | glucuronide conjugation (glucuronadation) |
| cytochrome p450 | phase 1 enzyme |
| non cyp enzymes (e.g. alcohol dehydogenase, xanthine oxide) | phase 1 enzyme |
| UDP glucuronosyl transferase | phase 2 enzyme |
| sulfotransferase | phase 2 enzyme |
| methyl transferase | phase 2 enzyme |
| acetyl transferase | phase 2 enzyme |
| Acyl CoA: glycine N-acyl transferase | phase 2 enzyme |
| gluthathione s-transferase | phase 2 enzyme |
| aromatic hydroxylation | phase 1 pathway |
| aliphatic hydroxylation | phase 1 pathway |
| oxidative N-dealkylation | phase 1 pathway |
| oxidative O-dealkylation | phase 1 pathway |
| S-oxidation | phase 1 pathway |
| reduction | phase 1 pathway |
| hydrolysis | phase 1 pathway |
Created by:
Kachmiel
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