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Chapter 11 Rau's
Corticosteroid Agent
Question | Answer |
---|---|
Adrenal Cortical Hormones | Chemicals secreted by the adrenal cortex, referred to as steroids. |
Endogenous | Refers to inside - produced by the body. |
Exogenous | Refers to outside - manufactured to be placed inside the body(E.G., Medication) |
Immunoglobulin E (IgE) | Gamma globulin that is produced by Cells in the respiratory tract. |
Prostaglandin | One of several hormone-type substances circulating throughout the body. |
Steroids | Also known as Glucocorticoids or corticorsteroids, agents that produce an antiinflammatory response in the body. |
Steroid Diabetes | Hyperglycemia (e.g., increased plasma glucose levels) resulting from glucocorticoid therapy; glucocorticoids break down proteins and fats to generate building blocks for gluconeogenesis. |
Physiology of endogenous corticosteroids involves | a sequence of stimulation of the adrenal cortex through the hypothalamic-pituitary-adrenal (HPA) axis, in which increased blood levels of corticosteroid inhibit the HPA and adrenal cortex from further secretion. |
Corticosteroids are secreted | By the adrenal cortex including: glucocorticoids (e.g., cortisol) mineralocorticoids (e.g., aldosterone) |
Glucocorticoids | often referred to simply as steroids, exert an antiinflammatory effect in the body. |
What can Exogenous corticosteroids suppress? | The HPA axis and the adrenal gland. |
Levels of endogenous corticosteroids | Follow a daily, or diurnal, rhythm. |
What does inflammation produce? | General symptoms of redness, swelling, heat and pain. |
What mediators further amplify the inflammatory response. | arachidonic acids cascade (Prostaglandins and leukotrienes); histamine; and various cytokines, such as interleukins. |
Areosolize glucocorticoids all are | Topically active drugs and include beclomethasone dipropionate, triamcinolone acetonide, flunisolide, budesonide, fluticasone propionate, and mometasone furoate. |
Aerosol agents are available for | oral inhalation in the control of asthma and COPD and intranasal administration for rhinitis. |