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Chapter 11 Rau's

Corticosteroid Agent

Adrenal Cortical Hormones Chemicals secreted by the adrenal cortex, referred to as steroids.
Endogenous Refers to inside - produced by the body.
Exogenous Refers to outside - manufactured to be placed inside the body(E.G., Medication)
Immunoglobulin E (IgE) Gamma globulin that is produced by Cells in the respiratory tract.
Prostaglandin One of several hormone-type substances circulating throughout the body.
Steroids Also known as Glucocorticoids or corticorsteroids, agents that produce an antiinflammatory response in the body.
Steroid Diabetes Hyperglycemia (e.g., increased plasma glucose levels) resulting from glucocorticoid therapy; glucocorticoids break down proteins and fats to generate building blocks for gluconeogenesis.
Physiology of endogenous corticosteroids involves a sequence of stimulation of the adrenal cortex through the hypothalamic-pituitary-adrenal (HPA) axis, in which increased blood levels of corticosteroid inhibit the HPA and adrenal cortex from further secretion.
Corticosteroids are secreted By the adrenal cortex including: glucocorticoids (e.g., cortisol) mineralocorticoids (e.g., aldosterone)
Glucocorticoids often referred to simply as steroids, exert an antiinflammatory effect in the body.
What can Exogenous corticosteroids suppress? The HPA axis and the adrenal gland.
Levels of endogenous corticosteroids Follow a daily, or diurnal, rhythm.
What does inflammation produce? General symptoms of redness, swelling, heat and pain.
What mediators further amplify the inflammatory response. arachidonic acids cascade (Prostaglandins and leukotrienes); histamine; and various cytokines, such as interleukins.
Areosolize glucocorticoids all are Topically active drugs and include beclomethasone dipropionate, triamcinolone acetonide, flunisolide, budesonide, fluticasone propionate, and mometasone furoate.
Aerosol agents are available for oral inhalation in the control of asthma and COPD and intranasal administration for rhinitis.
Created by: Kemashea