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Adrenergix

meep

QuestionAnswer
β2 Selective Agonists SA: albuterol, terbutaline, metaproterenol. LA: salmeterol + formoterol. Treat asthma/COPD and pre-term labor. SEs: tremors (skeletal muscle desensitization) and tachycardia (BRR)
Isoproterenol Non-selective β agonist. Not used to treat asthma due to tachycardia
Phenylephrine α1 agonist. Vasoconstriction treats severe hypotension and prevents surgical bleeding
Tetrahydrozaline α1 agonist. Vasoconstriction treats red eye
Naphazoline α1 agonist. Vasoconstriction treats nasal congestion
Clonidine α2 agonist. Neg feedback to NE decreases vasoconstriction to treat HTN
Epinephrine β1/β2/α1/α2. Slight vasodilation (β2 > α1) and tachycardia (β1 + BRR). Behaves like NE at high doses (α1 > β2)
Norepinephrine β1/α1/α2. Vasoconstriction (α1) and bradycardia (BRR > β1)
Amphetamine + Methamphetamine Releasing agent - release of NE/epi with longer DoA (less susceptible to MAO) and inc lipophilicity
Cocaine Reuptake inhibitor - potentiates NE, epi, and DA
Selegiline MOA inhibitor - potentiates NE
Entacapone COMT inhibitor - potentiates NE
Ephedrine Mixed acting - β1/β2/α1/α2 agonist (~Epi vasodilation/tachycardia) and NE/epi releasing agent. SEs: CNS innervation (e.g. insomnia). Contraindicated in BPH
Created by: 1148100386
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