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Drug intro review
drug intro
| Question | Answer |
|---|---|
| Chemical Name | description of the chemical composition, molecular structure,most detailed name |
| Generic Name | by manufacturer,becomes official name |
| Trade/proprietary name | copyrighted name |
| Official Name | followed by USP or NF |
| Pure Food and Drug Act (1906) | protects public from mislabeled drugs,restricts sale of drugs with potential for abuse |
| Harrison Narcotic Act (1914) | Regulates sale,importation and manufacturing of drugs that produce dependency |
| Federal Food,Drug and cosmetic act (1938) | Prevents marketing before a drug is tested,requires ingredients to be printed on labels and directions |
| Durham-Humphrey Amendments (1951) | requires pharmacists to have written or verbal prescriptions from dr's |
| Controlled substance act (1970) | regulates addictive medications, classified drugs into 5 schedules |
| 6 Rights for administration | RIGHT:medication,dose,time,route, patient,documentation |
| Teratogenic Agents | Alcohol,anti thyroid drugs,lithium,streptomycin,tetracycline |
| Active Transport | Energy required to move a substance,ATP is broken down to ADP,energy is released |
| Facilitated diffusion | Carrier proteins on cell membrane allow large molecules to bind to them, once bound the large molecules can enter cell |
| Passive transport | Most drugs (substances) move in this manner |
| Omosis | Solvent from low to high concentration |
| Diffusion | Solutes move from high to low concentration |
| Filtration | Molecules from high to low pressure, hydrostatic pressure |
| Rate of absorption depends on | 1.The cell membrane 2.Blood flow to the site 3.solubility of the drug 4. Ph of the drug environment 5.Drug concentration |
| Organs richest in blood supply | Heart, Liver, Kidney and brain |
| Purpose of a drug reservoir | To intensify the effects and the duration of a drug effect |
| Factors that effect drug binding (Distribution) | 1.Concentration of plasma proteins, 2. # of biding sites on proteins 3.Drugs affinity to protein 4.Acid base balance of pt 5.Liver disease |
| The primary organ for biotransformation | (The liver) also plasma,kidneys,lungs and intestinal mucosa |
| The primary organ for excretion | (kidneys) also intestine,lungs and glands |
| Half life | The amount of time required to metabolite and eliminate half the drug dose |
| Therapeutic Index | The ration between the lethal dose and the effective dose |
| Pharmacokinetics components | Absorption, distribution, bio transformation and excretion |
| Public Health service | responsible for regulation of biological products such as viruses and therapeutic serums |
| Subcutaneous injection is introduced into | beneath the skin below the dermis |
| Federal Trade commission | Responsible for the truthfulness of drug advertising claims |
| LEAN drugs | lidocaine,Epinephrine,Atropine, narcan and vasopressin |
| 3 Processes of Renal Excretion | 1.Filtration 2.Re absorption 3.Secretion |
| Factors that influence Drug actions | 1.Route of administration 2.The pH 3.Rate of absorption and blood flow |
| Enteral Route | Through the GI tract |
| Parenteral Route | by injection |
| SQ volume of injection | 0.5-1 mls |
| IM injection volume | 5 mls |
| Factors that delay parenteral absorption | Shock,acidosis,hypothermia |
| Factors that increase parenteral absorption | Hyperthermia,fever |
| Therapeutic threshold | The minimum concentration of any drug necessary to cause a desired affect |
Created by:
rebeccabelleth
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