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AD drugs

Alzheimer Drugs

QuestionAnswer
Elimination of Donepezil [Aricept] Metabolized by hepatic cytochrome P450
Elimination of Rivastigmine [Exelon] Metabolized by cholinesterase, Causes “irreversible” inhibition of cholinesterase.
Elimination of Galantamine Metabolized by hepatic cytochrome P450 and excreted by the kidneys
Memantine (NMDA Antagonist) Excreted by the kidneys
How do Donepazil, Rivastigmine and Galantamine work? They inhibit cholinesterase, increases amount of acetylcholine
NMDA N-methyl-d-aspartate
Drugs that block cholinergic receptors first-generation antihistamines, tricyclic antidepressants, conventional antipsychotics
Common risk-factors for rivastigmine, donepazil and galentamine: bradycardia, fainting, falls, and fall-related fractures
Memantine memantine is indicated only for moderate or severe AD
Created by: ekm
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