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Parkinson Drugs

QuestionAnswer
Levodopa Converted into dopamine, can cross blood brain barrier
Carbidopa Prevents degradation of Levodopa in PNS
Apomorphine dopamine agonists, used for rescue therapy during "off" times
Pramipexole, Ropinorole dopamine agonists, first-line drugs, or supplement to levodopa,
bromocriptine, carbergoline less selective dopamine agonist, ergot derivatives
Tolcapone Inhibit breakdown of levodopa by COMT
Entacapone Safer and more effective than tolcapone.
Selegiline, Rasaginline MAO-B inhibitor, used to manage off times
Amantadine Promotes release of dopamine(DA), can block DA reuptake
COMPT stands for what? Catechol-O-Methyltransferase
How does carbidopa work? It supresses decarboxylate activity to allow more levodopa to get to the CNS.
What side-effect can extra carbidopa reduce? Nausea and vomiting caused by levodopa.
Created by: ekm
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