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Absorption Meds going into bloodstream via GI Tract, muscle, skin, or subcutaneous tissue
Distribution Transportation of meds to sites by body fluids
Metabolism Changes meds into less active/inactive forms by action of enzymes. Occurs primarily in liver, can also be in kidneys, lungs, bowel, and blood.
Excretion Elimination of meds from body primarily through kidneys. may also take place in liver, lungs, bowel, and exocrine glands
Plasma Protein binding meds compete for protein binding site within bloodstream, mainly albumin
therapeutic effect what we desire the outcome to be.
side effect not main reason drug is given. unwanted outcome.
adverse effect side effect has adverse/bad effect on person (vomiting, blindness, etc..)
Toxic effect specific risk when too much drug is in system
medication interaction how meds work/interact with other drugs, food, alcohol, etc..
minimum effective concentration smallest amount of drug that will achieve desired effect
toxic concentration amount of drug that is too much, that it becomes toxic to a person
therapeutic range actual amount between minimum effect and toxic effect
therapeutic index increased has wide safety margin, no need for routine serum meds level monitor. decreased should have serum med level monitored closely. (peak and trough)
half-life period of time needed for med to be reduced by 50% in body. may be affected by liver and kidney funtion
agonist drug turning something on. causes something to happen (increase blood sugar, etc..)
partial agonist blocks/stops thins from happening in body (decreased heart rate)
generic name used in most drug books (ibuprofen)
trade name brand name (Motrin, Advil, etc..)
prescription drugs must have licensed Dr write script. controlled distribution, have more effect
over-the-counter drugs may be sold at grocery store, safer, less strong
FDA Food & Drug Administration
Teratogen substances that are harmful to unborn fetus.
Created by: klevans21