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gout meds

QuestionAnswer
uricosurics (probenecids) increase excretion or uric acid
allupurinol reduces uric acid production by altering the breakdown of purines
NSAIDS or colchicine stops inflam response
gout DOC NSAIDS
colhicine narrow ther window
corticosteroids reserved for unable to tol NSAIDS/colchecine
probenecid dont start 1st 2-3 weeks, will intensify and prolong inflammation
allupurinol dont start in acue phase, will prolong attack
concurrent admin rec allupurinol or probenecid and colchicineNSAID in chronic
colchicin can cause reversble malabsorption of B12
allupurinol take with food
gero start all at lowest rec. dose
colchi. GI tox in 80% of pts
peds probenecid contrai. if <2, can give to increase actions of PCN and ceph.
peds do not give allupurinol for inborn purine metab
probenecid cat B
NSAIDS can mask infection
Colchicine start at 1st sign of attack
colchicine bone marrow suppression
allupurinol lg doses vit C increases kidney stones
allupurinol take with food or milk
allupurinol takes 6 weeks to benefit
anturane enhance oral diab. meds > hypoglycemia
DOC for tophi allupurinol
Created by: keoughrn
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