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AntiretroviralsPTCE
| Question | Answer | |
|---|---|---|
| Nucloside Reverse Transcriptase Inhibitors (NRTIs) | MOA: inhib release of neuraminidase (viral enzyme) to prevent spread of virus to healthy cells, forming defective proviral nucleus AR: Nausea and vomiting, peripheral Neuropathy | |
| abacavir (ABC) | Ziagen | NRTI solution, tab |
| didanosine (ddl) | Videx, Videx EC | NRTI cap, tab, powder |
| emtricitabine (FTC) | Emtriva | NRTI tab |
| lamivudine (3TC) | Epivir | NRTI tab, solution |
| stavudine (d4T) | Zerit | NRTI cap, powder |
| tenofovir (TDF) | Viread | NRTI Tab |
| zalcitabine (ddC) | Hivid | NRTI tab |
| zidovudine (AZT) | Retrovir | NRTI Cap, syrup, IV |
| abacavir-lamivudine | Epzicom | NRTI Tab |
| emtricitabine-tenofovir | Truvada | NRTI Tab |
| zidovudine-lamivudine (CBV) | Combivir | NRTI Tab |
| zidovudine-lamivudine-abacavir (TRZ) | Trizivir | NRTI Tab |
| Nonnucleoside Reverse Transcriptase Inhibitors (NNRTIs) | MOA: inhib action of neuraminidase preventing the formation of proviral DNA AR: dizziness, headache, rashes, nightmares, hallucinations, hepatotoxicity | SPECIAL: drug interactions common, induce or inhibit cytochrome P450 if resistant to one NNRTI then resistant to all other |
| delaviridine (DLV) | Rescriptor | NNRTI cap, tab |
| efavirenz (EFZ) | Sustiva | NNRTI cap |
| nevirapine (NVP) | Viramune | NNRTI cap, tab |
| Protease Inhibitors | MOA: prevent cleavage of certain HIV protein precursors (rep of new viruses) AR: redist of body fat (protease paunch), facial atrophy, breast enlargement, hyperglycemia, hyperlipidemia | |
| amprenavir | Agenerase | Protease Inhibitors cap, liquid |
| atazanavir | Reyataz | Protease Inhibitors Cap |
| fosamprenavir (FPV) | Lexiva | Protease Inhibitors Tab |
| indinavir (IDV) | Crixivan | Protease Inhibitors cap |
| lopinavir-ritonavir (LPV/r) | Kaletra | Protease Inhibitors solution, cap |
| nelfinavir (NFV) | Viracept | Protease Inhibitors powder, tab |
| ritonavir (RTV) | Norvir | Protease Inhibitors solution, cap |
| saquinavir (SQV-SGC) | Invirase | Protease Inhibitors cap |
| lopinavir-ritonavir | Kaletra | Protease Inhibitors Cap, solution, tab |
| Fusion Inhibitor | MOA: prevents AIDs virus from entering immune cells SPECIAL: pregnancy cat B rating, dilute w sterile water | |
| enfuvirtide | Fuzeon | fusion inhibitor |
| Antiretroviral | CI: limits progression of retroviruses that cause HIV/AIDs |
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