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ACHE Inhibitors
Cholinesterase Inhibitors
Question | Answer |
---|---|
What are the reversible cholinesterase inhibitors used to treat Myasthinia Gravis? | Neostigmine, Ambenonium, Edrophonium, Pyridostigmine |
What are the reversible cholinesterase inhibitors used to treat Alzheimer's? | Donepezil, Galentamine, Rivastigmine, Tracine |
What's an irrevesible cholinesterase inhibitor? | Echothiosphate |
Used to treat myasthenia gravis: | Ambenonium, Edrophonium, neostigmine |
Why are cholinesterase inhibitors so dangerous? | They are highly lipid soluble and can pass through membrane easily. They bind to the cholinesterase for a long time. |
Ambenomium | myasthenia gravis |
Edrophonium | myasthenia gravis |
Neostigmine | myasthenia gravis |
Pyridostigmine | myasthenia gravis |
Physiostigmine | Similar to neostgmine |
Therapeutic Use of irrevesible cholinesterase inhibitor: | Glaucoma treatment |
Echothiophate | Use to treat glaucoma |
Toxic effects of cholinesterase inhibitors | Overstimulation of muscarinic receptors |
What drug can be used to treat an overdose? | Pralidoxime. |
Tracine | Used to treat alzheimers |
Donepezil | Used to stimulate ach receptors in the CNS |