Drugs for Biochem Word Scramble
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Question | Answer |
Inhibits both COX-1 and COX-2, but does not reduce inflammation | Acetaminophen |
Inhibits COX-1 slightly more than COX-2 | Acetaminophen |
Inhibits transcription and replication by physically obstructing polymerase | Actinomycin D |
A class of polypeptide antibiotic, derived from soil bacteria of the genus Streptomyces | Actinomycin D |
Binds DNA at the transcription initiation complex and interferes with DNA replication | Actinomycin D |
Suicide inhibitor of xanthine oxidase | Allopurinol |
Prevents hyperuricemia | Allopurinol |
Inhibits xanthine oxidase | Allopurinol |
Inhibits eukaryotic mRNA synthesis | alpha-amanitin |
Product of toxic mushroom, Amanita phalloides | alpha-amanitin |
Binds to RNA pol II and inhibits elongation | alpha-amanitin |
Used as a research tool to investigate mRNA synthesis | alpha-amanitin |
Inhibits COX-1 | Aspirin |
Inhibits peptide bond formation by peptidyltransferase (23S rRNA) between the P site peptide and the A site amino acid | Chloramphenicol |
Inhibits translation by inhibiting peptidyltransferase (50S) in prokaryotes | Chloramphenicol |
Inhibits peptidyltransferase | Chloramphenicol (prokaryotes) and Cyclohexamide (eukaryotes) |
Inhibits peptidyltranferase (50S) in prokayrotes | Chloramphenicol |
Inhibits DNA gyrase | Ciprofloxacin |
Inhibits peptidyltransferase | Cycloheximide |
Inhibits eukaryotic peptidyl transferase | Cycloheximide |
Inihibits translation by inhibiting peptidyltransferase (eukaryotic 60S) in eukaryotes | Cycloheximide |
Inhibits peptidyltransferase (60S) in eukaryotes. | Cycloheximide |
Interferes with the translocation step in protein synthesis | Cycloheximide |
Interferes with movement of two tRNA molecules and mRNA in relation to the ribosome | Cycloheximide |
Blocks translational elongation by inhibiting peptidyltransferase (60S) in eukaryotes | Cycloheximide |
Prevents translocation of aa-tRNA to the A site of ribosomes | Erythromycin |
Inhibits translation by binding to the entrance of the exit tunnel on the 50S subunit blocking elongation | Erythromycin |
Inhibits translation by preventing translocation (50S) in prokaryotes | Erythromycin |
Prevents translocation (50S) in prokaryotes | Erythromycin |
Inhibitor of dihydrofolate reductase | Methotrexate |
Inhibits dihydrofolate reductase | Methotrexate |
Competitive inhibitor of human dihydrofolate reductase | Methotrexate |
Increases extracellular adenosine | Methotrexate |
Inhibits peptide bond formation by binding to the A-site and inducing peptide bond formation causing premature termination of translation | Puromycin |
Causes chain termination in both prokaryotes and eukaryotes | Puromycin |
Inhibts translation by causing premature termination with a tyrosinyl-tRNA analog in both eukaryotes and prokaryotes | Puromycin |
Premature termination (tyrosinyl-tRNA analog) in both prokaryotes and eukaryotes | Puromycin |
Inhibits bacterial RNA polymerase and is therefore used to treat tuberculosis | Rifampin (rifampicin) |
Inhibits bacterial RNA polymerase | Rifampin (rifampicin) |
An inhibitor of prokaryotic RNA polymerase | Rifampin (rifampicin) |
Class of drugs that inhibit HMG-CoA due to a structural similarity to mevalonate | Statins |
HMG-CoA reductase inhibitor | Statins |
A class of hypolipidemic drugs used to lower cholesterol levels | Statins |
Inhibits HMG-CoA reductase | Statins |
Inhibits the rate-limiting enzyme of the mevalonate pathway of cholesterol synthesis | Statins |
Prevents initiation of translation and causes misreading of codons | Streptomycin |
Causes misreading of codons and inaccurate initiation | Streptomycin |
Inihibits initiation in bacteria | Streptomycin |
Inhibits translation by preventing initiation and causing misreading (30S) | Streptomycin |
Prevents initiation and causes misreading (30S) in prokaryotes. | Streptomycin |
Inhibits elongation in bacteria by inhibiting GTP hydrolysis to relase EF-Tu from the ribosome | Tetracycline |
Inhibits translation by prevent aminoacyl-tRNA binding (30S) in prokaryotes | Tetracycline |
Inhibits binding of aminoacyl-tRNA to A site of ribosomes | Tetracycline |
Prevent aa-tRNA binding (30S) in prokaryotes | Tetracycline |
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