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Drugs for Biochem

Drugs for Biochem class

QuestionAnswer
Inhibits both COX-1 and COX-2, but does not reduce inflammation Acetaminophen
Inhibits COX-1 slightly more than COX-2 Acetaminophen
Inhibits transcription and replication by physically obstructing polymerase Actinomycin D
A class of polypeptide antibiotic, derived from soil bacteria of the genus Streptomyces Actinomycin D
Binds DNA at the transcription initiation complex and interferes with DNA replication Actinomycin D
Suicide inhibitor of xanthine oxidase Allopurinol
Prevents hyperuricemia Allopurinol
Inhibits xanthine oxidase Allopurinol
Inhibits eukaryotic mRNA synthesis alpha-amanitin
Product of toxic mushroom, Amanita phalloides alpha-amanitin
Binds to RNA pol II and inhibits elongation alpha-amanitin
Used as a research tool to investigate mRNA synthesis alpha-amanitin
Inhibits COX-1 Aspirin
Inhibits peptide bond formation by peptidyltransferase (23S rRNA) between the P site peptide and the A site amino acid Chloramphenicol
Inhibits translation by inhibiting peptidyltransferase (50S) in prokaryotes Chloramphenicol
Inhibits peptidyltransferase Chloramphenicol (prokaryotes) and Cyclohexamide (eukaryotes)
Inhibits peptidyltranferase (50S) in prokayrotes Chloramphenicol
Inhibits DNA gyrase Ciprofloxacin
Inhibits peptidyltransferase Cycloheximide
Inhibits eukaryotic peptidyl transferase Cycloheximide
Inihibits translation by inhibiting peptidyltransferase (eukaryotic 60S) in eukaryotes Cycloheximide
Inhibits peptidyltransferase (60S) in eukaryotes. Cycloheximide
Interferes with the translocation step in protein synthesis Cycloheximide
Interferes with movement of two tRNA molecules and mRNA in relation to the ribosome Cycloheximide
Blocks translational elongation by inhibiting peptidyltransferase (60S) in eukaryotes Cycloheximide
Prevents translocation of aa-tRNA to the A site of ribosomes Erythromycin
Inhibits translation by binding to the entrance of the exit tunnel on the 50S subunit blocking elongation Erythromycin
Inhibits translation by preventing translocation (50S) in prokaryotes Erythromycin
Prevents translocation (50S) in prokaryotes Erythromycin
Inhibitor of dihydrofolate reductase Methotrexate
Inhibits dihydrofolate reductase Methotrexate
Competitive inhibitor of human dihydrofolate reductase Methotrexate
Increases extracellular adenosine Methotrexate
Inhibits peptide bond formation by binding to the A-site and inducing peptide bond formation causing premature termination of translation Puromycin
Causes chain termination in both prokaryotes and eukaryotes Puromycin
Inhibts translation by causing premature termination with a tyrosinyl-tRNA analog in both eukaryotes and prokaryotes Puromycin
Premature termination (tyrosinyl-tRNA analog) in both prokaryotes and eukaryotes Puromycin
Inhibits bacterial RNA polymerase and is therefore used to treat tuberculosis Rifampin (rifampicin)
Inhibits bacterial RNA polymerase Rifampin (rifampicin)
An inhibitor of prokaryotic RNA polymerase Rifampin (rifampicin)
Class of drugs that inhibit HMG-CoA due to a structural similarity to mevalonate Statins
HMG-CoA reductase inhibitor Statins
A class of hypolipidemic drugs used to lower cholesterol levels Statins
Inhibits HMG-CoA reductase Statins
Inhibits the rate-limiting enzyme of the mevalonate pathway of cholesterol synthesis Statins
Prevents initiation of translation and causes misreading of codons Streptomycin
Causes misreading of codons and inaccurate initiation Streptomycin
Inihibits initiation in bacteria Streptomycin
Inhibits translation by preventing initiation and causing misreading (30S) Streptomycin
Prevents initiation and causes misreading (30S) in prokaryotes. Streptomycin
Inhibits elongation in bacteria by inhibiting GTP hydrolysis to relase EF-Tu from the ribosome Tetracycline
Inhibits translation by prevent aminoacyl-tRNA binding (30S) in prokaryotes Tetracycline
Inhibits binding of aminoacyl-tRNA to A site of ribosomes Tetracycline
Prevent aa-tRNA binding (30S) in prokaryotes Tetracycline
Created by: P1StudyStack on 2008-12-14



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