Gram - Spirochetes
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| Flap 2 |
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| Gram - Spirochetes |
Borrelia burgdorferi, Treponema pallidum, Leptospirosis interrogans |
| Borrelia burgdorferi: Labs |
Lyme Serology- EIA and Western Blot |
| Borrelia burgdorferi: Toxins |
Lipid A/LOS, OspA--> OspC |
| Borrelia burgdorferi: Acute Disease |
Fever, Bull's eye rash, Myalgias and arthralgias, Meningeal irritation |
| Borrelia burgdorferi: Chronic Disease |
Meningoencphalitis, myocarditits, and disabling recurrent arthritis |
| Borrelia burgdorferi: Disease |
Lyme Disease |
| Borrelia burgdorferi: Treatment |
Oral doxycycline, ceftriaxone, amoxicillin, or erythromycin |
| Treponema pallidum: Labs |
Microaerophilic, Dark field immunoflourescent microscopy, RPR, VDRL |
| Treponema pallidum: Toxins |
Endotoxins, Hyaluronidase |
| Treponema pallidum: Primary disease |
Painless chancre that is contagious |
| Treponema pallidum: Secondary disease |
headache, Maculo-papular centripetal rashes, Arthralgias |
| Treponema pallidum: Latent disease |
Condyloma lata appear with recurrences |
| Treponema pallidum: Congenital disease |
Transplacental transmission |
| Treponema pallidum: Tertiary disease |
Neurosyphilis, Gummatous, and Cardiovascular disease |
| Treponema pallidum: Treatment |
Benzathine Penicillin, Pen G, Doxycycline |
| Leptospira interrogans: Labs |
Obligate aerobe |
| Leptospira interrogans: Toxins |
Endotoxins, Hyaluronidase |
| Leptospira interrogans: Acute disease |
Flu-like febrile illness with bacteremia |
| Leptospira interrogans: Recurrent disease |
Fever, Aseptic meningitis |
| Leptospira interrogans: Treatment |
Penicillin G, Doxycycline, Ceftriaxone |
| Leptospira interrogans: Transmission |
Zoonotic transmission |
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