| Question | Answer |
| Gram - Spirochetes | Borrelia burgdorferi, Treponema pallidum, Leptospirosis interrogans |
| Borrelia burgdorferi: Labs | Lyme Serology- EIA and Western Blot |
| Borrelia burgdorferi: Toxins | Lipid A/LOS, OspA--> OspC |
| Borrelia burgdorferi: Acute Disease | Fever, Bull's eye rash, Myalgias and arthralgias, Meningeal irritation |
| Borrelia burgdorferi: Chronic Disease | Meningoencphalitis, myocarditits, and disabling recurrent arthritis |
| Borrelia burgdorferi: Disease | Lyme Disease |
| Borrelia burgdorferi: Treatment | Oral doxycycline, ceftriaxone, amoxicillin, or erythromycin |
| Treponema pallidum: Labs | Microaerophilic, Dark field immunoflourescent microscopy, RPR, VDRL |
| Treponema pallidum: Toxins | Endotoxins, Hyaluronidase |
| Treponema pallidum: Primary disease | Painless chancre that is contagious |
| Treponema pallidum: Secondary disease | headache, Maculo-papular centripetal rashes, Arthralgias |
| Treponema pallidum: Latent disease | Condyloma lata appear with recurrences |
| Treponema pallidum: Congenital disease | Transplacental transmission |
| Treponema pallidum: Tertiary disease | Neurosyphilis, Gummatous, and Cardiovascular disease |
| Treponema pallidum: Treatment | Benzathine Penicillin, Pen G, Doxycycline |
| Leptospira interrogans: Labs | Obligate aerobe |
| Leptospira interrogans: Toxins | Endotoxins, Hyaluronidase |
| Leptospira interrogans: Acute disease | Flu-like febrile illness with bacteremia |
| Leptospira interrogans: Recurrent disease | Fever, Aseptic meningitis |
| Leptospira interrogans: Treatment | Penicillin G, Doxycycline, Ceftriaxone |
| Leptospira interrogans: Transmission | Zoonotic transmission |
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