biochem
Quiz yourself by thinking what should be in
each of the black spaces below before clicking
on it to display the answer.
Help!
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HbA1 | normal adult hemoglobin - a heterotetramer
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HbS | sickle cell hemoglobin Glu replaced by Val in the B chain
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Chaperones | helps refold newly synthesized proteins and misfolded proteins.
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Cis-trans-prolpyl isomerases | interconvert cis and trans peptide bonds of proline residues.
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Protein disulfide isomerases | catalyze breakage and formation of disulfide cysteine bonds
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heat shock proteins(Hsp) | help refold proteins that heat has misfolded them(powered by ATP)
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glycosylation | carbohydrates
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hydroxylation | hydroxyl groups
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phosphorylation | phosphoryl groups
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methylation | methyl groups
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proteolysis | cleaving protein chain
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specific sequence glycosylated is | Asn-X-Thr/Ser
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N-linked glycosylation occurs at | cotranslationally
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O-linked glycosylation occurs later in the | Golgi apparatus postranslational
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Mannose 6-phosphate determines the lysosomal destination | targeting of enzymes to lysosomes
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insulin are produced in the | pancreatic islet cells
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The A-chain of insulin begins with | Gly
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The B-chain of insulin beings with | Phe
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Procollagens contain the repeating tripeptide sequence | Gly-X-Y several hundred times.
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Desmosine cross-link contains | three allysines and one lysine
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PEST protieins(rich in P,E,S and T) | are also rapidly degraded.
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Calpains involves | perform limited proteolysis
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Caspases involves | apoptosis(programmed cell death) can activate cysteine aspartyl proteases
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proteasome | degrades cell proteins that are marked for degradtion by ubiquitination or other means
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lysosomes | organelle rich in hydrolytic enzymes for degrading and recycling unneeded cell components
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Created by:
rxfuture949
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