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Regulation of FA synthesis and storage

Quiz yourself by thinking what should be in each of the black spaces below before clicking on it to display the answer.

Glucokinase synthsis is induced by ___________   insulin  
PFK2 is activated to make Fructose-2,6 bisphosphate by _____________   insulin  
Fructose-2,6 bisphosfate activates   PFK  
Pyruvate kinase is active when dephosphoylated at   high insulin/glucagon ratios  
Pyruvate dehdyrogenase is induced by   insulin in addition to intracellular activation  
Excess NADH in the fed state will inhibit _______ in the Kreb cycle   isocitrate dehydrogenase  
Inhibition of isocitrate dehydrogenase causes a build up of ____________.   Citrate  
FA synthesis is induced by _____________   insulin  
Acetyl CoA Carboxylase Regulation (4)   1. CoA carboxylase synthesis is induced by insulin. 2. active when dephosphorylated/inactive when phosphorylated 3. allosterically inhibited by palmitoyl CoA 4. Allosterically activated by citrate  
What inhibits carnitine trasport of fatty acyl groups into the mitochondrion   Malonyl CoA  
Lipoprotein lipase synthesis and secretion is induced by ____________.   Insulin  
Lipoprotein lipase occurs where?   capillary endothelial cells and in adipose and skeletal muscle tissues  
Whihc has lower Km --> adipose lipoprotein lipase or muscle lipoprotein lipase   Skeletal muscle lipoprotein lipase  
What happens to FA in muscle   breakdown to CO2 and H2O  
What happens to FA in adipose   TG storage  
Insulin's effect on adipocytes   increases glucose availability for glycerol 3 phosphate synthesis  


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Created by: Todd Jamrose Todd Jamrose on 2008-10-17

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