Regulation of FA synthesis and storage
Quiz yourself by thinking what should be in
each of the black spaces below before clicking
on it to display the answer.
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| Glucokinase synthsis is induced by ___________ | insulin
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| PFK2 is activated to make Fructose-2,6 bisphosphate by _____________ | insulin
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| Fructose-2,6 bisphosfate activates | PFK
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| Pyruvate kinase is active when dephosphoylated at | high insulin/glucagon ratios
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| Pyruvate dehdyrogenase is induced by | insulin in addition to intracellular activation
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| Excess NADH in the fed state will inhibit _______ in the Kreb cycle | isocitrate dehydrogenase
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| Inhibition of isocitrate dehydrogenase causes a build up of ____________. | Citrate
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| FA synthesis is induced by _____________ | insulin
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| Acetyl CoA Carboxylase Regulation (4) | 1. CoA carboxylase synthesis is induced by insulin.
2. active when dephosphorylated/inactive when phosphorylated
3. allosterically inhibited by palmitoyl CoA
4. Allosterically activated by citrate
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| What inhibits carnitine trasport of fatty acyl groups into the mitochondrion | Malonyl CoA
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| Lipoprotein lipase synthesis and secretion is induced by ____________. | Insulin
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| Lipoprotein lipase occurs where? | capillary endothelial cells and in adipose and skeletal muscle tissues
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| Whihc has lower Km --> adipose lipoprotein lipase or muscle lipoprotein lipase | Skeletal muscle lipoprotein lipase
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| What happens to FA in muscle | breakdown to CO2 and H2O
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| What happens to FA in adipose | TG storage
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| Insulin's effect on adipocytes | increases glucose availability for glycerol 3 phosphate synthesis
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Created by:
tjamrose
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