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WVSOM - Biochem

Regulation of FA synthesis and storage

Glucokinase synthsis is induced by ___________ insulin
PFK2 is activated to make Fructose-2,6 bisphosphate by _____________ insulin
Fructose-2,6 bisphosfate activates PFK
Pyruvate kinase is active when dephosphoylated at high insulin/glucagon ratios
Pyruvate dehdyrogenase is induced by insulin in addition to intracellular activation
Excess NADH in the fed state will inhibit _______ in the Kreb cycle isocitrate dehydrogenase
Inhibition of isocitrate dehydrogenase causes a build up of ____________. Citrate
FA synthesis is induced by _____________ insulin
Acetyl CoA Carboxylase Regulation (4) 1. CoA carboxylase synthesis is induced by insulin. 2. active when dephosphorylated/inactive when phosphorylated 3. allosterically inhibited by palmitoyl CoA 4. Allosterically activated by citrate
What inhibits carnitine trasport of fatty acyl groups into the mitochondrion Malonyl CoA
Lipoprotein lipase synthesis and secretion is induced by ____________. Insulin
Lipoprotein lipase occurs where? capillary endothelial cells and in adipose and skeletal muscle tissues
Whihc has lower Km --> adipose lipoprotein lipase or muscle lipoprotein lipase Skeletal muscle lipoprotein lipase
What happens to FA in muscle breakdown to CO2 and H2O
What happens to FA in adipose TG storage
Insulin's effect on adipocytes increases glucose availability for glycerol 3 phosphate synthesis
Created by: tjamrose

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