| Question |
Answer |
| Inhibits both COX-1 and COX-2, but does not reduce inflammation |
Acetaminophen |
| Inhibits COX-1 slightly more than COX-2 |
Acetaminophen |
| Inhibits transcription and replication by physically obstructing polymerase |
Actinomycin D |
| A class of polypeptide antibiotic, derived from soil bacteria of the genus Streptomyces |
Actinomycin D |
| Binds DNA at the transcription initiation complex and interferes with DNA replication |
Actinomycin D |
| Suicide inhibitor of xanthine oxidase |
Allopurinol |
| Prevents hyperuricemia |
Allopurinol |
| Inhibits xanthine oxidase |
Allopurinol |
| Inhibits eukaryotic mRNA synthesis |
alpha-amanitin |
| Product of toxic mushroom, Amanita phalloides |
alpha-amanitin |
| Binds to RNA pol II and inhibits elongation |
alpha-amanitin |
| Used as a research tool to investigate mRNA synthesis |
alpha-amanitin |
| Inhibits COX-1 |
Aspirin |
| Inhibits peptide bond formation by peptidyltransferase (23S rRNA) between the P site peptide and the A site amino acid |
Chloramphenicol |
| Inhibits translation by inhibiting peptidyltransferase (50S) in prokaryotes |
Chloramphenicol |
| Inhibits peptidyltransferase |
Chloramphenicol (prokaryotes) and Cyclohexamide (eukaryotes) |
| Inhibits peptidyltranferase (50S) in prokayrotes |
Chloramphenicol |
| Inhibits DNA gyrase |
Ciprofloxacin |
| Inhibits peptidyltransferase |
Cycloheximide |
| Inhibits eukaryotic peptidyl transferase |
Cycloheximide |
| Inihibits translation by inhibiting peptidyltransferase (eukaryotic 60S) in eukaryotes |
Cycloheximide |
| Inhibits peptidyltransferase (60S) in eukaryotes. |
Cycloheximide |
| Interferes with the translocation step in protein synthesis |
Cycloheximide |
| Interferes with movement of two tRNA molecules and mRNA in relation to the ribosome |
Cycloheximide |
| Blocks translational elongation by inhibiting peptidyltransferase (60S) in eukaryotes |
Cycloheximide |
| Prevents translocation of aa-tRNA to the A site of ribosomes |
Erythromycin |
| Inhibits translation by binding to the entrance of the exit tunnel on the 50S subunit blocking elongation |
Erythromycin |
| Inhibits translation by preventing translocation (50S) in prokaryotes |
Erythromycin |
| Prevents translocation (50S) in prokaryotes |
Erythromycin |
| Inhibitor of dihydrofolate reductase |
Methotrexate |
| Inhibits dihydrofolate reductase |
Methotrexate |
| Competitive inhibitor of human dihydrofolate reductase |
Methotrexate |
| Increases extracellular adenosine |
Methotrexate |
| Inhibits peptide bond formation by binding to the A-site and inducing peptide bond formation causing premature termination of translation |
Puromycin |
| Causes chain termination in both prokaryotes and eukaryotes |
Puromycin |
| Inhibts translation by causing premature termination with a tyrosinyl-tRNA analog in both eukaryotes and prokaryotes |
Puromycin |
| Premature termination (tyrosinyl-tRNA analog) in both prokaryotes and eukaryotes |
Puromycin |
| Inhibits bacterial RNA polymerase and is therefore used to treat tuberculosis |
Rifampin (rifampicin) |
| Inhibits bacterial RNA polymerase |
Rifampin (rifampicin) |
| An inhibitor of prokaryotic RNA polymerase |
Rifampin (rifampicin) |
| Class of drugs that inhibit HMG-CoA due to a structural similarity to mevalonate |
Statins |
| HMG-CoA reductase inhibitor |
Statins |
| A class of hypolipidemic drugs used to lower cholesterol levels |
Statins |
| Inhibits HMG-CoA reductase |
Statins |
| Inhibits the rate-limiting enzyme of the mevalonate pathway of cholesterol synthesis |
Statins |
| Prevents initiation of translation and causes misreading of codons |
Streptomycin |
| Causes misreading of codons and inaccurate initiation |
Streptomycin |
| Inihibits initiation in bacteria |
Streptomycin |
| Inhibits translation by preventing initiation and causing misreading (30S) |
Streptomycin |
| Prevents initiation and causes misreading (30S) in prokaryotes. |
Streptomycin |
| Inhibits elongation in bacteria by inhibiting GTP hydrolysis to relase EF-Tu from the ribosome |
Tetracycline |
| Inhibits translation by prevent aminoacyl-tRNA binding (30S) in prokaryotes |
Tetracycline |
| Inhibits binding of aminoacyl-tRNA to A site of ribosomes |
Tetracycline |
| Prevent aa-tRNA binding (30S) in prokaryotes |
Tetracycline |
Biology Lab Midterm
