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Wound Healin'

USCSOM: Pathology: Wound Healing

Question	Answer
What is the main difference between regeneration and healing via fibrosis?	fibrosis is replacement by connective tissue with scarring
What is the most effective method of increasing growth rate?	recruiting G0 cells back into cell cycle
What are labile cells?	continuously dividing, stem cells
What are the types of cells that are non-dividing?	nerve, skeletal muscle, cardiac
What are quiescent cells?	Stable cells
Where do adult stem cells reside?	niches
What is granulation tissue?	hallmark of healing, fibroblasts, angiogenesis and edema
What is VEGF?	vascular endothelial growth factor; stimulates proliferation and motility of endothelial cells
What does Ang 1/Tie2 do?	receptor on endothelial cell; promotes maturation of vessels
What does Ang2/Tie2 do?	w/VEGF stimulates proliferation; w/o VEGF inhibits
What is PDGF?	platelet derived growth factor; recruits smool muscle cells
What hormones induce VEGF expression?	TGF-alpha, TGF-beta, PDGF, hypoxia
What is the most important angiogenesis factor?	TGF-Beta; migration, proliferation, collagen
What are TIMPs and what do they do?	tissue inhibitor of metalloproteases; regulate collagen breakdown
What are the three phases of wound healing?	inflammation, formation of granulation tissue, ECM remodeling
What are some early characteristics of healing by primary union/first intention in first 24 hours?	scab, edema, lots of neutrophils
What are some early characteristics of healing by primary union/first intention by day 3?	macrophages; beginning of granulation tissue; fibroblasts produce glycopreteins
What are some early characteristics of healing by primary union/first intention by day 5?	all granulation tissue; new vessels formed; collagen increases
What are some early characteristics of healing by primary union/first intention by second week?	Granulation disappears; edema recedes; collagen formed
What are some early characteristics of healing by primary union/first intention by first month?	scar formed; cross linking of collagen;
What things can inhibit healing?	infection; foreign body; poor vascular supply; corticosteroids
What is keloid?	excessive formation of collagen at the site of a wound
What is proud flesh?	excessive granulation tissue formation

Created by:

Justin Ellerman on 2009-08-24

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Wound Healin'

USCSOM: Pathology: Wound Healing