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Antibiotic Classes
Clinical Micro Antibiotcs
Question | Answer |
---|---|
How do Sulfonamides act as a competitive antagonist? | Sulfonamides are structurally similar to the protein p-aminobenzoic acid, which is essential for bacterial folate synthesis. Sufonamides competitively bind the enzyme that catalyzes folate synthesis, forming non- functional folic acid |
What antibiotics/antibiotic classes inhibit protein synthesis? | Chloramphenicol, Tetracycline, Macrolides, and Aminoglycosides |
What antibiotic is used to treat Pseudomonas? | Carbenicillin |
What are SXT, Nirtofuradantin, and Nalidixic Acid used to treat and why? | Used primarily against UTIs and are completely excreted through the urinary tract with no measurable concentation in serum |
What are the aminoglycosides and what issues can they cause? | Tobramycin, Gentamicin, Kanamycin, Amikacin, and Streptomycin. They are nephrotoxic and ototoxic. |
What is the mode of action of Quinolones and why shouldn't they be given to children under 18? | They inhibit DNA synthesis and can interfere with developing bones or cause tendon rupture in children under 18. |
What are the Sulfonamides and their alternate names? | Gantrisin or Sulfisoxazole Trimethoprim or TMP Sulfamethoxazole or SMX Septra/SXT or Sulfamethoxazole Trimethoprim |
What antibiotics interfere with cell wall synthesis? | Penicillin, Cephalsporins, and Vancomycin |
What is indifference? | The combined action of two antibiotics is no greater than that of the more effective antibiotc when used alone (1 + 1 = 1) |
Why shouldn't tetracycline be given to pregnant women and children under 8? | Tetracycline can permanently discolor developing teeth and bones |