click below
click below
Normal Size Small Size show me how
Inflammation & n-3FA
Question | Answer |
---|---|
Name the substrates for eicosanoid synthesis | Arachidonic Acid and Eicosapentaenoic Acid |
What are the 4 main sub-groups of eicosanoids? | Leukotrienes, Thromboxanes, Prostacyclins, Prostaglandins |
What are Toll Like Receptors? | Primary sensors of the innate immune system |
Where are Leukotrienes synthesized and what is their function? | Leukocytes - Inflammation inducer, chemotaxis & adherance inducer |
Where are Thromboxanes synthesized and what is their function? | Platelets- stimulates platelet aggregation/thrombosis |
Where are Prostacyclins synthesized and what is their function? | Endothelial cells of blood vessels- antithrombotic, relaxes arterial wall |
Where are Prostaglandins synthesized and what is their function? | Epithelial cells of stomach wall- helps regulate stomach acid secretion |
What is the difference between eicosanoids synthesised by n-6 and n-3 fatty acids | The ones synthesised from n-3 have a lesser inflammatory response |
How do n-3 fatty acids help with inflammation? (5) | 1. decrease production of AA derived eicosanoids 2. increase production of EPA derived eicosanoids 3. Increase production of resolvins 4. Decrease generation of inflammatory cytokines 5. Decrease leukocyte chemotaxis and generation of ROS |
What are resolvins and what do they do? | They are endogenous mediators synthesised from n-3 PUFAs that promote active resolution of inflammation. They reduce neutrophil infiltration and inflammatory cytokines |
Name some dietary sources of ALA | Oils (flaxseed & walnut), walnuts, plant foods rich in polyphenols |
Name some dietary sources of EPA/DHA | Fatty fish & fish oil |
What are Eicosanoids and what do they do? | Short lived hormones synthesised from 20C fatty acids that bring about inflammatory changes |
What are cytokines? | Small proteins produced from many cell types that act as signals for other cells |
What are the main pro-inflammatory cytokines? | Interferon , IL-6, IL-1 and TNF |
What are the essential fatty acids and why are these essential? | Linoleic acid (LA) and alpha-linolenic acid (ALA). Humans can't synthesise the original double bonds in them. |
What is cyclooxygenase (COX)? | The enzyme responsible for making eicosanoids |
What is the difference between COX1 and COX2? | COX1 is expressed continually (but at very low levels), COX2 is only expressed when there is an insult/injury |
What are the major nutritional issues associated with NSAID use? | Stomach ulceration/bleeding, clots/thrombosis |
What are the major nutritional issues associated with glucocorticoid use? | increased fat mass, increased muscle catabolism, decreased insulin sensitivity |