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Intro + Carbohy.
Biochemistry, Medicine, Phase 1
Term | Definition |
---|---|
Monomers (1) | a type of molecule that bonds to other molecules to form polymers; the most basic biomolecule |
Monomers (2) | sugars, nucleotides, fatty acids, amino acids |
Polymers (1) | made up of smaller subunits of molecules |
Polymers (2) | glycogen, RNA and DNA, tricylgycerols, phospholipids, proteins |
Sugar monomers | glucose, fructose |
Sugar polymer | glycogen, sucrose |
Stearic acid | example of a fatty acid |
Fatty acids and fatty acid polymers | function in long-term fat storage; structural component of membranes |
Sugars | function in short-term fuel for muscle, brain, kidney, etc. |
RNA and DNA | genetic information |
Other biomolecules | cholesterol/ steroid hormones, vitamins, co-factors, xenobiotics |
Carbohydrates (Sugars) | monosaccharides; water soluble (hydrophilic and polar), function as an energy source (glucose) or a energy storage module (glycogen); structurally part of cell walls in bacteria |
Protein function of sugars | cell surface proteins are often glycosylated (e.g. ABO blood groups and IgG |
(CH2O)n | general formula for carbohydrates; usually 3, 4, 5 or 6 |
Triose C3 (sugars) | glyceraldehyde, dihydroxyacetone |
Pentose C5 (sugars) | ribose |
Hexoses C6 (sugars) | glucose, fructose |
Aldose and ketose | Isomers (same chemical formula) |
Aldoses | sugar, isomer molecule, contains the aldehyde group (−CH=O), glucose is an example; |
Ketoses | contains the keto group, example is fructose |
−CH=O | Aldehyde group |
Cn(H2O)n | Aldose chemical formula |
Aldoses | they have at least one asymmetric carbon center, aldoses with three or more carbon atoms exhibit stereoisomerism |
Stereoisomers | isomeric molecules that have the same molecular formula and sequence of bonded atoms (constitution), but differ in the three-dimensional orientations of their atoms in space; make only minor changes in the chemical properties of the sugar |
d- form or l- form | aldoses containing stereogenic centers can exist in either; d-sugar is more common in biological organisms; humans use d-sugar |
C6H1206 | glucose chemical formula |
galactose, mannose | isomers for glucose; differ only in their spatial arrangements around one or two carbon atoms |
Isomer differences | recognised by enzymes and other proteins are therefore can have important biological effects |
Optical isomers | mirror-image pairs of molecules |
Glycosidic bonds | link together monosaccharides; glycosyltransferase links the two monosaccharides together and results in the production of water |
Disaccharides | two linked monosaccharides; e.g. sucrose = fructose + glucose |
Condensation reaction | in which a molecule of water is expelled as the bond is formed; when an -OH group on one sugar and an -OH ground on another form a bond; also used by nucleic bonds; reverse process of hydrolysis |
Carbonyl group | located in the middle of a ketose on the end of an aldose |
Carbon 1 | carbon at the end closest to the carbonyl group |
Linear form | make up less than 1% of hexoses |
Anomeric carbon | carbon attached to the original carbonyl group in cyclic form |
Ring formation | in aqueous solution, the aldehyde or ketone group of a sugar molecule tends to react with a hydroxyl group of the same molecule, thereby closing the molecule into a ring |
alpha and beta forms | the hydroxyl group on the carbon that carries the aldehyde or ketone group can rapidly change from one position to another; these are the two positions; become frozen when a sugar bonds |
alpha form | hydroxyl group is facing up |
beta form | hydroxyl group is facing down |
Monosaccharides | glucose, fructose, galactose |
Disaccharide | sucrose (glucose + fructose), maltose (glucose + glucose), lactose (galactose + glucose) |
Polysaccharides | glycogen (branched glucose polymer), amylose (linear glucose polymer) |
Glycosidic bond formation of maltose | alpha-D-glucose + alpha-D-glucose; water is produced; the first glucose bonds at carbon 1 and the other at carbon 4 |
Reducing sugar | if an anomeric carbon is not attached to another molecule; the aldehyde or ketose group is free; all monosaccharides |
Glycogen | glucose polysaccharide, linear glucose polymer (alpha 1>4) with alpha (1>6) branchs |
Step 1 of digestion of glycogen in diet | digestion of alpha-amylase random hydrolysis of internal alpha (1>4) linkages |
Step 2 of digestion of glycogen in diet | pancreatic alpha-amylase mixture of mono and disaccharides continues hydrolysis of internal alpha (1>4) linkages |
Step 3 of digestion of glycogen in diet | maltase produces glucose which can absorbed by the intestinal mucosal cells |
Mobilisation of glycogen in the liver | glycogen phosphorylase hydrolyses terminal alpha (1>4) to produce glucose-1-phosphate |
Lactose intolerance | normally lactase: lactose > galactose and glucose; undigested lactose can be digested by bacteria in the large intestine producing excess carbon dioxide and other metabolites which result in bloating and diarrhoea |