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SLE
SLE OT
| SLE | 1 | 2 | 3 | 4 | 5 | 6 |
|---|---|---|---|---|---|---|
| Systemic lupus erythematosus | chronic inflammatory condition affecting joint surfaces and vessel walls seen predominantly in women and young children | genetic predisposition , seen in relatives with HLADR2 and HLADR3 antigens | most common immunologic feature is production of ANA- immune complexes responsible for renal and cutaneous manifistations, tissue specific antibodies that cause hemolysis(RBC break down=brown urine) and thrombocytopenia(decreased platelets bleed rightaway | effects joints and kidneys, serous surfaces, and vessel walls | etiology is unkown | ANA + |
| systemic manifestations include | fatigue | malaise | weight loss | fecer without signs of infection | (blank) | (blank) |
| cutaneous manifestations | malar or butterfly rash exacerbated by exposure to sun | discoid rash ( chicken skin) | patchy alopecia (regional balding) | (blank) | (blank) | (blank) |
| joint manifestations | arthritis- symmetric primarily involving hands, wrist , and knees | ligament laxity leads to joint deformaties | raynaud's phenomenon - alternate red and whitediscoloration of skin secondary to exposure to cold weather | (blank) | (blank) | (blank) |
| renal manifistation | nephritic syndrome (Blood urea Nitrogen increases, lipid loss causes hypolipidemia, sensorial deterioration so drowsy and comatose, decrease albumin increases edema) | renal failure ( can't produce urin) | (blank) | (blank) | (blank) | (blank) |
| neurologic manifistation | behavioral and cognitive disturbances | activive cerebritis( encephalitis) | neuropathies cranial and peripheral | (blank) | (blank) | (blank) |
| git manifestation | nasea | abdominal pain 2 to steril peritonitis | (blank) | (blank) | (blank) | (blank) |
| Cardio pulmonary manifestation | pleuritis ( infl lung tissue) | pneumonitis ( infl lung) | pericarditis | endocarditis ( infl of heart valves) | (Libman sacs endocarditis) | (blank) |
| hematologic manifestation | hepatosplenomegaly | normochronic, normocytic anemeia ( normal number and size of rbc can't sustain O2 | leukopenia ( dec WBC) | thrombocytopenia ( dec platelets) | (blank) | (blank) |
| treatment | steroids and cytotoxic agents ( azthioprine , cyclophosphomide) for ppl with kidney problems, hemolytic anemia, and thrombocytopenia | antimalarial agent for cutaneus manifistation and arthritis 9 hydroxycloroquin) | analgesics like ASA, NSAID, or ibuprofin for mild systemic symptoms | side effect of acytyl salilic acid is salycylate hepatitis | side effect for nsaid is acute renal failure | side effect for ibuprofin is aseptic meningitis |
Created by:
natkat
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