complement Word Scramble

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Question	Answer
What complement compound is in both the classic and alternative pathway?	C3
What is the goal of complement?	lysis (or removal) of cells coated with specific antibody
What activates the alternative complement pathway?	c3b (coated pathogen)
Which complement protein acts as an opsonin	c3b- Bb-C3bP
What is cleaved by C3b-Bb	C3
What is the order of activation in the lectin activation pathway	MBL, c4, C2, C3
What is first cleaved by Clqrs in the classical pathway	c4
What initiates complement activation in the lectin pathway	Mannose binding Lectin
what is cleaved by c4b2a3b	c5
Which complement proteins are not used in the alternative pathway?	c1, c2, c4
deficiency in C2 would lead to what disease?	immune complex disease
What factors are only associated with the alternatice pathway?	factors B and D
what complement protein polymerizes to cause lysis of a foreign cell	C9 (last protein in attack complex)
The recognition unit in the classical complement pathway consists of what?	clqrs
Lack of complement inhibitor C1INH leads to	hereditary angiodema
what stabilizes C3 and C5 convertase in the alternative pathway?	properdin
what factor is the key intermediate in all pathways	c3
In the alternate pathway, factor B must bind to _____ to initiate the cascade	C3b
What must be associated with factor H to inactivate complement components?	factor 1
what factor helps dissociate C3b from RBC's	DAF (this doesn't happen in paroxysmal nocturnal hemoglobinuria)
What protein inhibits the classical pathway at the very beginning	C1INH
what is characteristic of complement proteins (what do they all do)	Complement proteins play a role in inflammatory response
which pathway is factor B in	alternative
Which pathway is properdin in	alternative
what pathway is C1, C4, C2 part of	classical

Created by: amandalk