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complement
for immunology test
| Question | Answer |
|---|---|
| What complement compound is in both the classic and alternative pathway? | C3 |
| What is the goal of complement? | lysis (or removal) of cells coated with specific antibody |
| What activates the alternative complement pathway? | c3b (coated pathogen) |
| Which complement protein acts as an opsonin | c3b- Bb-C3bP |
| What is cleaved by C3b-Bb | C3 |
| What is the order of activation in the lectin activation pathway | MBL, c4, C2, C3 |
| What is first cleaved by Clqrs in the classical pathway | c4 |
| What initiates complement activation in the lectin pathway | Mannose binding Lectin |
| what is cleaved by c4b2a3b | c5 |
| Which complement proteins are not used in the alternative pathway? | c1, c2, c4 |
| deficiency in C2 would lead to what disease? | immune complex disease |
| What factors are only associated with the alternatice pathway? | factors B and D |
| what complement protein polymerizes to cause lysis of a foreign cell | C9 (last protein in attack complex) |
| The recognition unit in the classical complement pathway consists of what? | clqrs |
| Lack of complement inhibitor C1INH leads to | hereditary angiodema |
| what stabilizes C3 and C5 convertase in the alternative pathway? | properdin |
| what factor is the key intermediate in all pathways | c3 |
| In the alternate pathway, factor B must bind to _____ to initiate the cascade | C3b |
| What must be associated with factor H to inactivate complement components? | factor 1 |
| what factor helps dissociate C3b from RBC's | DAF (this doesn't happen in paroxysmal nocturnal hemoglobinuria) |
| What protein inhibits the classical pathway at the very beginning | C1INH |
| what is characteristic of complement proteins (what do they all do) | Complement proteins play a role in inflammatory response |
| which pathway is factor B in | alternative |
| Which pathway is properdin in | alternative |
| what pathway is C1, C4, C2 part of | classical |
Created by:
amandalk