NAPLEX-20 (Diabetes) Word Scramble

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Question	Answer
ADA goal for AIC	<7%
goal estimated average glucose	<154 mg/dl
preprandial blood glucose	70-130 mg/dl
how frequent urine test for albumin	annual
aspirin therapy for prevention for what age group	men >50yo, female >60 age
Glucovance	metformin + glyburide
actoplus Met	pioglitazone + metformin
Janumet	sitagliptin + metformin
Glumetza	Metformin
Fortamet	metformin
glucophage	metformin
contraindication of metformin	scr>1.5 (male), >1.4 (female) or CrCl <60ml/min
caution and bbw for metformin	caution with HF, bbw- lactic acidosis
metformin ER rec to be taken daily of when in the day?	daily at evening
Glumetza and Fortamet - counseling point of seeing medicine in the stool	glumetza-shell of medicine in stoll fortamet- looks like a lumpy tablet in the stool not a problem... medicine has been absorbed
Sulfonylureas SHOULD NOT be used with what other antidiabetic drug class d/t to similar MOA?	MEGITINIDES (secreatogues)
Diabinese	Chlorpropamide - older agent. not used anymore d/t long duration and risk for hypoglycemia
Glucotrol, Glucotrol XL	Glipizide
Amaryl	Glimpiride
Diabeta	Glyburide
Micronase. Which has better absorption?	micronized has better absorption. Glyburide
What two drug classes are not recommended for use by ADA d/t long-lasting hypoglycemia?	Diabinese (Chlorpropamide) and (Diabeta, Micronase) Glyburide *partially active metabolite that can accumulate in renal dysfxn (CrCl<50)
Prandin	Meglitinides
actos	pioglitazone
Duetact	Pioglitazone + Glimepirmide (Amaryl) = Duetact
Avandia	Rosiglitazone
MOA of TZDs? Which TZDs are better for lipids?	pioglitazone; increase insulin sensitivity
Common S/E to TZDs?	Hepatic & Cardiovascular risk
Which drug class may take several weeks to see results of blood sugar lowering?	TZDs
Precose. MOA?	Acarbose. MOA: inhibit alpha-glucosidase in the intestine and amylase in the pancreas- delayed absorption of glucose. inhibit metabolism of sucrose to glucose and frutose
T/F: Titrate Acarbose (Precose) & Miglitol (Glyset) should be titrated slowly d/t GI effects	True
What is the advantage of using alpha-glucosidase inhibitors?	increase HDL, decrease TG and total cholesterol & don't cause weight gain!
Which med class can't lower blood sugar themselves?	Alpha-glucosidase inhibitor
If you get low blood sugar with alpha-glucosidase inhibitors, you can't treat hypoglycemia with sucrose form of sugar	True.
januvia	sitagliptin
Juvisync	sitagliptin + simvastatin
side effects to januvia	- nasopharyngitis, upper respiratory tract infections, peripheral edema, rash, hypoglycemia - weight neutral
what are incretin enhancers vs. incretin mimetics?	DPP4 inhibitors and GLP-1 agonists (extenidtide-byetta; victoza -liraglutide)
Byetta (class?)	Exenatide
(class?) Liraglutide	victoza
Primary side effect to Byetta? Top S/e involves? Should be avoided in...	Exenatide- NAUSEA * note: other known side effects: PANCREATITIS, RENAL (AVOID IN SEVERE IMPAIRMENT CrCl <30ml/min)
Which med requires a MedGuide? Should not be used in a special patient population?	dont use in pts with hx of pancreatitis, gallstones, alcoholism, or high TGs (REQUIRES MedGuide!!!) avoid in severe renal impairment
Symlin (generic, class)	Pramlintide
Unique use of Symlin? Comes in two different dosage form	Pramlintide (amylinomimetic)- mimics the hormone that mangages post-prandial glucose SymlinPen 120 (Type 2) SymlinPen 60 (Type 1) * can be use in BOTH TYPE 1 AND 2 DM
common s/e to Symlin?	- hypoglycemia - nausea - anorexia (d/t preventing glucagon increase)
There's a diet restriction when using Pramlintide. what is it?	Only use if you consumed > or equal 250 kcal or >or equal 30grams of carbohydrates/day
What Bile-acid binding resin may possibly help with glycemic control?	- Colesevelam (Welchol)

Created by: tang4884