Med Biochem Enzymes Word Scramble

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Enzyme	Reaction/Fxn	Pathway
Hexokinase	Glucose --> G-6-P	Glycolysis
Phosphoglucoisomerase	G-6-P <---> F-6-P	Glycolysis/Gluconeogenesis
Phosphofructokinase (PFK)	F-6-P --> F-1,6-bisP	Glycolysis
Aldolase	F-1,6-bisP <----> Glyceraldehyde 3-phosphate & Dihydroxyacetone Phosphate	Glycolysis/Gluconeogenesis
Triose Phosphate Isomerase	Dihydroxyacetone Phosphate <----> Glyceraldehyde 3-phosphate	Glycolysis/Gluconeogenesis
Glyceraldehyde 3-phosphate Dehydrogenase	Glyceraldehyde 3-phosphate <---> 1,3 Bisphosphoglycerate	Glycolysis/Gluconeogenesis
Phosphoglycerate Kinase	1,3 Bisphosphogycerate <---> 3-phosphoglycerate	Glycolysis/Gluconeogenesis
Pyruvate Kinase	Phosphoenolpyruvate(PEP) --> Pyruvate	Glycolysis
Pyruvate Carboxylase	Pyruvate --> Oxaloacetate	Gluconeogenesis
Phosphoenolpyruvate Carboxykinase (PEPCK)	Oxaloacetate --> Phosphoenolpyruvate (PEP)	Gluconeogenesis
Fructose 1,6-bisphosphatase	F-1,6-bisP --> F-6-P	Gluconeogenesis
Glucose 6-phosphatases	G-6-P --> Glucose	Gluconeogenesis
Pyruvate Dehydrogenase (E1)	TPP + Pyruvate --> Hydroxyethyl-TPP	Pyruvate Dehydrogenase Complex
Dihydrolipoyl Transacetylase (E2	Acetyllipoamide + Coenzyme A --> Acetyl CoA	Pyruvate Dehydrogenase Complex
Dihyrolipoyl dehydrogenase (E3)	FAD + e --> FADH2 + Lipoamide ---[NAD+]---> NADH + (H+) + FAD	Pyruvate Dehydrogenase Complex
Citrate Synthase	Acetyl CoA + H2O + Oxaloacetate --> Citrate (C6)	TCA Cycle
Aconitase	Citrate --> Isocitrate (C6)	TCA Cycle
Isocitrate Dehydrogenase	Isocitrate --> alpha-Ketoglutorate (C5)	TCA Cycle
alpha-Ketoglutorate Dehydrogenase	alpha-Ketoglutorate --> Succinyl CoA (C4)	TCA Cycle
Succinyl CoA Synthetase	Succinyl CoA --> Succinate (C4)	TCA Cycle
Succinate Dehydrogenase	Succinate --> Fumarate (C4)	TCA Cycle
Fumarase	Fumarate --> Malate (C4	TCA Cycle
Malate Dehydrogenase	Malate --> Oxaloacetate (C4)	TCA Cycle
Phosphoglucomutase	G-1-P <---> G-1,6-P <---> G-6-P	Glycogen Synthesis
UDP-glucose Pyrophosphorylase	G-1-P + UTP ---> UDP-Glucose + PPi	Glycogen Synthesis
Glycogenin	Glucose + AA ---> dimer w/ Glycogen Synthase ---> +8 glucose residues ---> Glycogen Synthases finishes	Glycogen Synthesis
Glycogen Synthase	Glycogen(n) + UDP-glucose ---> UDP + Glycogen(n+1)	Glycogen Synthesis
Branching Enzyme	Cuts 7 terminal units off ---> forms alpha 1-6 linkage 4 units back	Glycogen Synthesis
G protein	+Adenylate cyclase	Glycogen Synthesis
Adenylate cyclase	ATP ---> cyclic AMP	Glycogen Synthesis
Cyclic AMP	+PKA	Glycogen Synthesis
PKA	+Phosphorylase kinase, -Glycogen synthase (b)	Glycogen Synthesis
Phosphorylase kinase	+Phosphorylase (a)	Glycogen Synthesis
Phosphorylase (a)	Glycogen(n) ---> Glucose 1-phosphate + Glycogen(n-1)	Glycogen Synthesis
PKA + Ca2+	++++ Phosphorylase kinase	Glycogen Synthesis
Protein phosphatase 1 (PP1)	-Phosphorylase kinase, -Phosphorylase (b), +Glycogen synthase	Glycogen Synthesis
Insulin-sensitive protein kinase	+PP1	Glycogen Synthesis
PP1	act* Glycogen synthase, inact* Phosphorylase kinase and Glycogen phosphorylase	Glycogen Synthesis
PKB	inact* GSK-3	Glycogen Synthesis
GSK3	inact* Glycogen synthase	Glycogen Synthesis
Panreatic (intestinal) lipases	TAGs ---> Fatty Acids	Lipoproteins
Lipoprotein lipase	cleaves TAGs (chylomicron) ---> FA + Glycerol	Lipoproteins
Apoprotein B-100	tag on lipoprotein, tells it where it is from	Lipoproteins
Chylomicrons	fatty acid packaging ---> circulatory system ---> liver	Lipoproteins
VLDL	repackaging of FAs, cholesterol and esters ---> circulatory system	Lipoproteins
IDL	after liporprotein lipases extract FAs, VLDL --> IDL and is transported to liver	Lipoproteins
LDL	after liporprotein lipases extract FAs, VLDL --> LDL and is transported to liver	Lipoproteins
HDL	pick-up and return cholesterol to the liver	Lipoproteins
ACAT	packages VLDL	Lipoproteins
LCAT	HDL scavages cholesterol	Lipoproteins
PKA	HSL and perilipin	Lipoproteins
Perilipin	changes conformation, allows lipase to enter lipid droplet	Lipoproteins
HSL	enters lipid droplet and cleaves FAs from TAGs	Lipoproteins
Albumin	Transports FAs in circulatory system	Lipoproteins
Lipase	adds water to TAG ---> glycerol + FAs	Lipoproteins
Fatty acyl-CoA synthetase	FA + ATP <--> Acyl adenylate + PPi <--> Acyl adenylate + CoA <--> Acyl CoA + AMP	FA Oxidation
Caritine acyltransferase I (CAT I)	Acyl CoA + Carnitine ---> Acyl carnitine + CoA	FA Oxidation
Translocase	moves Acyl carnitine into Matrix and Carnitine out to cytoplasm	FA Oxidation
Carnitine acyltransferase II (CAT II)	Acyl carnitine + CoA ---> Acyl CoA + Carnitine	FA Oxidation
Acyl-CoA dehydrogenase	Acyl CoA + FAD ---> trans-delta2-Enoyl CoA	FA Oxidation
Enoyl-CoA hydratase	trans-delta2-Enoyl CoA + H2O ---> L-3-Hydroxyacyl CoA	FA Oxidation
beta-Hydroxyacyl-CoA dehydronase	L-3-Hydroxyacyl CoA + NAD+ ---> 3- Ketoacyl CoA + NADH	FA Oxidation
Acyl-CoA acetyltransferase (thiolase)	3-Keyoacyl CoA + CoA ---> Acyl CoA + Acetyl CoA	FA Oxidation
delta3, delta2 -enoyl-CoA isomerase	converts cis-monosaturated FA ---> trans double bond, oxidizable by regular mechanism	FA Oxidation
Enoyl-CoA isomerase	acts on 1st db of polyunsaturated FAs and also trans-delta3	FA Oxidation
2,4-dienoyl-CoA reductase	works on the 2nd+ db bonds	FA Oxidation
Propionyl-CoA carboxylase	Propionyl-CoA + HCO3 + ATP ---(biotin)---> D-Methylmalonyl-CoA + ADP + Pi	Odd Chain FA
Methylmalonyl-CoA epimerase	D-Methylmalonyl-CoA ---> L-Methylmalonyl-CoA	Odd Chain FA
Methylmalonyl-CoA mutase	L-Methylmalonyl-CoA ---(B12)---> Succinyl-CoA	Odd Chain FA
Citrate Synthase	Acetyl-CoA + Oxaloacetate ---> Citrate	FA Biosynthesis
Citrate transporter	moves Citrate out of Mitochondria	FA Biosynthesis
Citrate Lyase	Citrate + CoA + ATP ---> Acetyl-CoA + ADP + Pi	FA Biosynthesis
Malate Dehydrogenase	Oxaloacetate + NADH + (H+) ---> Malate + NAD+	FA Biosynthesis
Malate-alpha-ketoglutarate transporter	Brings Malate into the matrix	FA Biosynthesis
Malic Enzyme	Malate + NADP+ ---> NADPH + (H+) + CO2 + Pyruvate	FA Biosynthesis
Pyruvate transporter	brings Pyruvate into matrix	FA Biosynthesis
Pyruvate Carboxylase	Pyruvate + CO2 + ATP ---> Oxaloacetate + ADP +Pi	FA Biosynthesis
Malate Dehydrogenase	Malate + NAD+ ---> Oxaloacetate + NADH + (H+)	FA Biosynthesis
Acetyl-CoA carboxylase	Acetyl-CoA + HCO3 + ATP ---> Malonyl-CoA + ADP + Pi + (H+)	FA Biosynthesis
Malonyl-CoA-ACP transacylase	Malonyl-CoA + ACP ---> Malonly-ACP + CoA	FA Biosynthesis
Acetyl-CoA-ACP transacylase	Acetyl-CoA + ACP ---> Acetyl-ACP + CoA	FA Biosynthesis
beta-Ketoacyl synthase (condensing)	Acetyl-ACP + Malonyl-ACP ---> Acetoacetyl-ACP + ACP + CO2	FA Biosynthesis
beta-Ketoacyl-ACP reductase	Acetoacetyl-ACP + NADPH ---> D-3-Hydroxbutyryl-ACP + NADP+	FA Biosynthesis
beta-Hydroxyacyl-ACP dehydratase	D-3-Hydroxybutyryl-ACP ---> H2O + Crotonyl-ACP	FA Biosynthesis
Fatty acyl-CoA desaturase	extracts electrons from 2 diff substrates and creates a double bond (saturated fatty acyl-CoA)	FA Biosynthesis
Carbamoyl phosphate synthetase I (CPS I)	Bicarbonate + ATP ---> Carboxyphosphate + NH3 ---> Carbamic acid + ATP ---> Carbamoyl phosphate	Pyrimidine Synthesis
Aspartate trans-carbamoylase (ATCase)	Carbamoyl phosphate + Aspartate ---> Carbamoylaspartate ---> Dihydroorotate + NAD+ ---> Orotate	Pyrimidine Synthesis
Orotate phosphoribosyl transferase	Orotate + 5--phosphoribosyl-1-pyrophosphate (PRPP) ---> Orotidylate	Pyrimidine Synthesis
Orotidylate decarboxylase	Orotidylate ---> Uridylate (UMP)	Pyrimidine Synthesis
UMP kinase	UMP + ATP ---> UDP + ADP	Pyrimidine Synthesis
Nucleoside diphosphate kinase	UDP + YTP ---> UTP + YDP	Pyrimidine Synthesis
Glutamine (NH3)	UTP + NH3 + ATP ---> CTP + ADP + Pi	Pyrimidine Synthesis
PRPP synthetase	Ribose 5-phosphate ---> PRPP	Purine Synthesis
Glutamine phosphoribosyl amidotransferase	PRPP + Glutamine ---> 5-Phospho-beta-D-ribosylamine	Purine Synthesis
IMP dehydrogenase	IMP ---> Xanthylate (XMP) + NH3 + ATP ---> Guanylate (GMP)	Purine Synthesis
Adenylosuccinate synthetase	IMP + GTP + Aspartate ---> Adenylsuccinate ---> Adenylate (AMP)	Purine Synthesis
HMG-CoA synthase	Acetoacetyl-CoA + Acetyl-CoA ---> HMG-CoA + CoA	Cholesterol Synthesis
HMG-CoA reductase	HMG-CoA ---> Mevalonate	Cholesterol Synthesis
Squalene synthase	Farnesyl pyrophosphate + Farnesyl pyrophosphate ---> Squalene (C30)	Cholesterol Synthesis
19 steps	Lanosterol --(19 steps)--> Cholesterol	Cholesterol Synthesis
ACAT	Cholesterol ---> Cholesteryl ester (LDL form)	Cholesterol Synthesis
Glutaminase	Glumanine ---> Glutamate + NH4+	AA Synthesis
Amino transferase + (PlP)	alpha-Ketoglutarate + Amino Acid ---> Glutamate + alpha-Keto acid	AA Synthesis
ALT	Pyruvate + Glutamate <---> Alanine (blood) + alpha-Ketoglutarate [moves amine between mucle and liver]	Cahill Cycle
Glutamate dehydrogenase	Glutamate <-[schiff base]--> NH4+ + alpha-Ketoglutarate	Urea Cycle
Carbamoyl phosphate synthetase-1	Bicarb + 2ATPs ---> ---> Carbamoyl phosphate	Urea Cycle-Mito
Ornithine transcarbamoylase	Orthine +Carbamoyl phosphate ---> Citrulline	Urea Cycle-Mito
Argininosuccinate synthetase	Citrulline + Aspartate + 2ATPS ---> Argininosuccinate	Urea Cycle-Cyto
Argininosuccinase	Argininosuccinate ---> Arginine + Fumarate	Urea Cycle-Cyto
Arginase	Arginine ---> Ornithine + Urea	Urea Cycle-Cyto
Pyridoxal phosphate (PLP)	co-enzyme for aminotransferase = transamination	Urea Cycle
Pyridoxamine phosphate	co-enzyme for aminotransferase = transamination	Urea Cycle
Glutamate dehydrogenase	Glutamate ---> [Schiff base] ---> alpha-Ketoglutarate + NH4+	Urea Cycle
ALT (PLP)	Tryptophan ---> Alanine ---> Pyruvate	AA Catabolism
Serine dehydratase (PLP)	Serine ---> Pyruvate	AA Catabolism
AA	Cysteine ---> Pyruvate	AA Catabolism
Serine hydroxylmethyl transferase	Threonine ---> Serine + Folate	AA Catabolism
Glycine cleavage enzyme	Glycine ---> NH4+ Folate	AA Catabolism
Phenylalanine hydroxylase (PKU)	Phenylalanine ---> Tyrosine	AA Catabolism
Homogentisate 1,2-dioxygenase (Alkaptonuria)	Homogentisate ---> Maleylacetoacetate	AA Catabolism
Glutamate dehydrogenase	a-Ketoglutarate ---> Glutamate	AA Synthesis
Glutamine synthetase	Glutatmate ---> Glutamine	AA Synthesis
ALT	Pyruvate ---> Alanine	AA Synthesis
AST	Oxaloacetate ---> Aspartate	AA Synthesis
Glutamine(NH3)	Aspartate ---> Asparagine	AA Synthesis
(no enzyme)	Glutamate ---> Ornithine <---> Proline <---> Ornithine <--- Arginine	AA Synthesis
(no enzyme)	3-Phosphoglycerate ---> 3-Phosphohydroxyl pyruvate ---> 3-phosphoserine ---> Serine	AA Synthesis
Serine hydroxylmethylase (PLP)	Serine + THF ---> Glycine + 5,10-methylTHF	AA Synthesis
Glycine synthase	CO2 + NH4 + 5,10-MethylTHF ---> Glycine + THF	AA Synthesis
SAM	Met + ATP ---> SAM	AA Synthesis
SAM	SAM + S-Ahomocysteine ---> Homocysteine	AA Synthesis
Methionine synthase (B12)	Homocysteine + N5-MethylTHF ---> Methionine + THF	AA Synthesis
none	Homocysteine + Serine ---> ---> Cysteine + a-Ketobutyrate	AA Synthesis
Tyrosine hydroxylase	Tyrosine ---> L-Dopa	Catacholamine Synthesis
Aromatic AA decarboxylase	L-Dopa ---> Dopamine	Catacholamine Synthesis
Dopamine hydroxylase	Dopamine ---> NorEpi	Catacholamine Synthesis
Ph-N-Methyltransferase	NorEpi ---> Epi	Catacholamine Synthesis
Aromatic AA decarboxylase	Tryptophan ---> Serotonin	Catacholamine Synthesis
Glutamate decarboxylase	Glutamate ---> GABA	Catacholamine Synthesis
Histadine decarboxylase	Histadine ---> Histamine	Catecholamine Synthesis
heme syn 1	Succinyl-CoA + Glycine ---> g-Aminolevulinate	Heme Synthesis
heme syn 2	(2) g-Aminolevulinate ---> Porphobilogen	Heme Synthesis
Porphobilinogen deaminase	Porphobilogen ---> linear Terapyrrole + 4NH3+	Heme Synthesis
Uroporphyrinogen synthase + (uroporphyrinogen III)	Uroporphyrinogen III (isoenzyme)	Heme Synthesis
heme syn 5	Uroporphyrinogen III + Methyl ---> Coproporphyrinogen III + Vinyl ---> Protoporhyrin IX	Heme Synthesis
Ferrochetalase	Protoporhyrin IX + Fe ---> Heme	Heme Synthesis
Heme oxygenase	Heme ---> Biliverdin + CO-	Heme Degradation
Biliverdin reductase	Biliverdin ---> Bilirubin	Heme Degradation
Glucuronyl-bilirubin transferase (liver)	Bilirubin changed - transported to intestine - changed back to Bilirubin (bile) ---> Urobilinogen ==> Stercobilin (feces), Urobilin (kidney-urine)	Heme Degradation
g-Glutanyl cysteine synthetase	Glutamate + Cystein ---> g-Glu-Cys	Glutathione Synthesis
Glutathione synthetase	g-Glu-Cys + Glycine ---> Glutathione (GSH)	Glutathione Synthesis
Glutathione peroxidase	GSH ---> GSSG (glutathione dimer w/ disulfide bridge)	Glutathione Synthesis
Glutathione reductase	GSSG ---> GSH	Glutathione Synthesis
Creatine kinase	Creatine phosphate + ADP <----> ATP + Creatine	Glutathione Synthesis
Ribonucleotide reductase	Ribonucleoside diphosphate ---> Deoxyribonucleoside diphosphate	Deoxyribonucleotide Syn
Thymidylate synthase	dUMP + 5,10-MethylTHF ---> dTMP + Dihydrofolate	Deoxyribonucleotide Syn
Dihydrofolate reductase	Dihydrofolate + NADPH ---> THF + NADP+	Deoxyribonucleotide Syn
none	THF + Serine ---> 5,10-MethylTHF + Glycine	Deoxyribonucleotide Syn
Fluorodeoxyuridylate	Thymidylate synthase inhibitor	Deoxyribonucleotide Syn
Aminopterin & methotrexate	Dihydrofolate reductase inhibitor	Deoxyribonucleotide Syn
Adenine phosphoribosyltransferase	Adenine + PRPP ---> Adenylate + PPi	Purine Salvage Pathway
Hypoxanthine-guanine phosphoribosyltransferase (HGPRT)	Hypoxanthine + PRPP ---> inosinate + PPi	Puine Salvage Pathway
HGPRT	Guanine + PRPP ---> Guanylate + PPi	Purine Salvage Pathway
Orotate phosphoribosyl transferase	Orotate + PRPP ---> Orotidylate	Pyrimidine Salvage Pathway
Xanthine Oxidase	AMP ---> IMP ---> Hypoxanthine ---> Xanthine ---> Uric acid ---> Urate	Purine Breakdown
Guanase	Guanine ---> Xanthine ---> Uric acid ---> Urate	Purine Breakdown
Allopurinol	Xanthine oxidase inhibitor = gout treatment	Gout treatment
Xanthine oxidase	Allopurinol ---> Alloxanthine	Gout treatment

Created by: ssherwo