CNS Pharmocology Word Scramble
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Question | Answer |
What physiologic effects of free radical molecules may result in damage or cell death? | peroxidation of lipids (p. 953) oxidative damage to DNA (p. 956) oxidation of LDL cholesterol (p. 956) - forms atherosclerotic plaque blood vessel injury (p. 198) |
Name three drugs or vitamins that may reduce damage produced by free radicals. | Vitamin C Vitamin E Selegiline Gingko Biloba |
Describe the possible sites of drug action on neurotransmission. | Modulate neurotransmitter release Modulate neurotransmitter clearance from the synaptic cleft Modulate effects of the neurotransmitter at the post-synaptic receptor |
Name two neurochemical strategies for drug therapy in Parkinson’s disease. | Increase DA activity Decrease Ach activity |
Which class of drug may be most useful in mild or early PD? | MAO-B inhibitors |
MAO-B Inhibitors | selegiline and rasagiline |
anticholinergic drugs | trihexyphenidyl bentztropine biperiden diphenhydramine |
Dopamine agonists | ergot derivatives: bromocriptine, pergolide non-ergot derivatives: pramipesole, ropinirole, apomorphine |
bromocriptine, pergolide | ergot derivatives, DA agonist for PD |
pramipesole, ropinirole, apomorphine | Non-ergot derivatives, DA agonist for PD |
carbidopa and entacapone | used together as a Levodopa (l-dopa) to decrease metabolism |
Name another clinical use for the antimuscarinics trihexyphenidyl and benztropine | reduce tremor and possibly rigidity in PD |
trihexyphenidyl and benztropine | antimuscarinic for PD |
Describe the mechanism of action for levodopa and carbidopa. | inhibits decarboxylation of levodopa in the intestine & peripheral tissues, thereby making more levodopa available to the CNS cannot pass BBB, therefore, does not prevent the conversion of levodopa to dopamine by decarboxylases in the brain |
L-dopa | ups DA enters brain via active transport system once in brain, drug undergoes uptake into the few dopaminergic nerve terminals that remain in the striatum then l-dopa converts to dopamine |
Describe early and late adverse effects of levodopa. | Early:N/V, postural hypotension Late: Dyskinesias in 1st yr. Loss of effectiveness, dysrhthmias, psychosis |
What are some strategies for dealing with loss of effectiveness in L-Dopa problems after 3-5 years of therapy? | ncrease total dosing or dose frequency Use sustained release formulations supplement with other PD medications Take a drug holiday |
Created by:
UCLAnurse
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