Pharm Histamine Word Scramble
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| Question | Answer |
| Name the Mast Cell Stabilizers | Cromolyn Na & Nedocromil –Tilade & Albuterol |
| Is this a 1 or 2 generation Hist antagonist? Ethanolamines:DIPHENHYDRAMINE (Benadryl) CLEMASTINE (Tavist) | 1st gen H1 antagonist |
| Is this a 1 or 2 generation Hist antagonist?Ethylenediamine:TRIPELENNAMINE | 1st gen H1 antagonist |
| Is this a 1 or 2 generation Hist antagonist?Alkylamine:CHLORPHENIRAMINE (Chlortrimeton) | 1st gen H1 antagonist |
| Is this a 1 or 2 generation Hist antagonist?Phenothiazine:PROMETHAZINE (Phenergan) | 1st gen H1 antagonist |
| Is this a 1 or 2 generation Hist antagonist? Piperazines: HYDROXYZINE (Vistaril) CYCLIZINE (Antivert) | 1st gen H1 antagonist |
| Is this a 1 or 2 generation Hist antagonist?CETIRIZINE (Zyrtec) | 2nd Gen H1 receptor antagonist |
| Is this a 1 or 2 generation Hist antagonist? FEXOFENADINE (Allegra) | 2nd Gen H1 receptor antagonist |
| Is this a 1 or 2 generation Hist antagonist? LORATADINE (Claritin) | 2nd Gen H1 receptor antagonist |
| Is this a 1 or 2 generation Hist antagonist? DESLORATADINE (Clarinex- FDA Approved In 2002) | 2nd Gen H1 receptor antagonist |
| Is this a 1 or 2 generation Hist antagonist? LORATADINE (Claritin Hives Relief - FDA Approved In 2004) | 2nd Gen H1 receptor antagonist |
| Is this a 1 or 2 generation Hist antagonist? AZELASTIN (Intranasal Spray) | 2nd Gen H1 receptor antagonist |
| Is this a 1 or 2 generation Hist antagonist? H1 or H2? Ranitidine | H2 Receptor Antagonists, there isnt a 1st or 2nd generation |
| Is this a 1 or 2 generation Hist antagonist? H1 or H2? Cimetidine | H2 Receptor Antagonists, there isnt a 1st or 2nd generation |
| Are 1st Generation H1 antagonist Sedative Or Non-Sedative? | Sedative |
| Are 2nd Generation H1 antagonist Sedative Or Non-Sedative? | Non-Sedative |
| Where is histamine stored and released? What cells? | Mast Cells, Basophils, Neurons (peripheral and central) |
| Where are H1 receptors located? | Smooth muscle, endothelium, CNS |
| Where are H2 receptors located? | gastric parietal cell, vascular sm cell, basophils |
| Where are H3 receptors located? | CNS cells, and some in peripheral NS |
| Where are H4 receptors located? | Highly expressed in bone morrow and white blood cells. |
| What are some uses of H1 antagonist (1st generation)? | Adjunct in anaphylaxis(H2 antagonist, epinephrine must also be used Antiallergy (allergic rhinitis, allergic dermatoses, contact dermatitis) Sedative/sleep aid To prevent motion sickness (meclizine, cyclizine) |
| Name even more uses of H1 antagonist (1st generation). | Antiemetic: prophylactic for motion sickness (promethazine) Antivertigo (meclizine) Local anesthetic: (diphenhydramine) Antitussive (diphenhydramine) |
| What are adverse effects of H1 1st generation drugs? | Sedation (Paradoxical excitation in children) Dizziness Fatigue Tachydysrhythmias in overdose - rare Allergic reactions with topical use Peripheral antimuscarinic effects dry mouth blurred vision constipation urinary retention |
| Describe drug interactions of H1 1st generation drugs. | Additive with classical antimuscarinics Potentiate CNS depressants opioids sedatives general and narcotic analgesics alcohol |
| What are the functions of H1 receptors | Bronchoconstriction, vasodilation, separation of endothelial cells, pain and itching, allergic rhinitis, motion sickness |
| What are the functions of H2 | Regulate gastric acid secretion, vasodilation, inhibition of IgE-dependent degranulation |
| What are the functions of H3 | Presynaptic, feedback inhibition of histamine synthesis and release. They also control release of DA, GABA, ACh, 5-HT & NE |
| What are the functions of H4 | Mediate mast cell chemotaxis |
| Why are the 1st generation H1 antagnist sedative? | Because the cross the blood/brain barrier and act on central NS. |
| Do 1st generation H1 antagonist have anti-muscarinic effects? | Yes, they do, and it can be additive with other anti-muscarinic drugs. |
| Sedation from H1 antagonist work on adults, however does it also do the same in children? If so Why? | No, it causes excitation, it is a paradoxical effect. |
| Why do 2nd generation drugs not have a sedative effect? | They do NOT cross the blood/brain barrier |
| what drugs end in -tidine? | H2 antagonists |
| What are other uses of 2nd generation antagonist? | These are used for peptic ulcer disease, stress ulcers, and for acid reflux. |
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shamd1
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