Gout Word Scramble
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| Question | Answer |
| Colchicine | Colcrys Gloperba Mitigare |
| Colchicine dosing | two 0.6 mg tablets followed by 1(0.6 mg) tablet in 1 hour |
| Do not exceed how much colchicine in 1 hour | 1.8 mg in 1 hr ` |
| When should youstart colchicine | within 36 hours of sympton onset |
| When can you resume prophylaxis after treatment with colchicine | 12 hrs after treatment |
| naproxen | Aleve |
| Indomethacin | indocin |
| Celecoxib | Celebrex |
| How are steriods given | IV, IM, PO, intra-articular or adrencorticotropic hormone |
| Methylpresnisionol | Medrol Solu-Medrol |
| Methprednisolone dosing | intra-articular if 1-2 large joimts involved |
| Canakinumab | llaris |
| Canakinumab MOA | interleukin 1 anatagonist |
| What must be done prior to canakinumab | TB testing |
| what must be avoided with canakinumab | live vaccines |
| Allopurinol | Zyloprim Aloprim |
| Allopurinol MOX | Xanthine oxidase inhibitor |
| Febuxostat | Uloric |
| Frbuxostat MOA | Xanthine Oxidase inhibitor |
| Xanthine Oxidase inhibitor | block xanthine oxidase enzyme to decrease uric acid production |
| If taking allopurinol pt should be screened for what gnee | HLA-B 5801 allel |
| UA target level | < 6 |
| Probenacid MOA | inhibits reabsorption of UA in the proximal tubule |
| Probenacid is | Uricosuric |
| Pegloticase is | recombinant uricase enzyme |
| Pegloticase MOA | coverts UA to an inactive metabolite allantoin that can be easily excreted |
| Who is pegloticase reserved for | severe refractory gout |
| which xanthine oxidase inhibitor causes increase in LFTs | Febuxostat ( Uloric) |
| Both xanthine oxidase inhibitors have warning for | hepatototoxicity SKin rash ( TEN, SJS, DRESS) |
| Probenacid can increase the levels of what other drug | beta lactam levels |
| Pegloticase | Krystexxa |
| Pegloticase formulation | IV |
| Krystexxa has boxed warning for | anaphylactic reaction: |
| How to prevent Krystexxa anaphylactic reaction | premedicate with antihistmaine and steroid |
| Pegloticase is contraindicated with | G6PD deficiency |
| which drugs should not be used with febuxostat | Mercaptopurine and azathiopurine |
| Pegloticase should be avoaided with | xanthine oxidase inhibitors and probenacid |
| colchincine side effects | Diarrhea, nausea, myopathy, neuropathy |
| Colchincine should be avoided with | strong CYP34 inhibitor and pgp inhibitors |
Created by:
annaiibarrera