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Gout

QuestionAnswer
Colchicine Colcrys Gloperba Mitigare
Colchicine dosing two 0.6 mg tablets followed by 1(0.6 mg) tablet in 1 hour
Do not exceed how much colchicine in 1 hour 1.8 mg in 1 hr `
When should youstart colchicine within 36 hours of sympton onset
When can you resume prophylaxis after treatment with colchicine 12 hrs after treatment
naproxen Aleve
Indomethacin indocin
Celecoxib Celebrex
How are steriods given IV, IM, PO, intra-articular or adrencorticotropic hormone
Methylpresnisionol Medrol Solu-Medrol
Methprednisolone dosing intra-articular if 1-2 large joimts involved
Canakinumab llaris
Canakinumab MOA interleukin 1 anatagonist
What must be done prior to canakinumab TB testing
what must be avoided with canakinumab live vaccines
Allopurinol Zyloprim Aloprim
Allopurinol MOX Xanthine oxidase inhibitor
Febuxostat Uloric
Frbuxostat MOA Xanthine Oxidase inhibitor
Xanthine Oxidase inhibitor block xanthine oxidase enzyme to decrease uric acid production
If taking allopurinol pt should be screened for what gnee HLA-B 5801 allel
UA target level < 6
Probenacid MOA inhibits reabsorption of UA in the proximal tubule
Probenacid is Uricosuric
Pegloticase is recombinant uricase enzyme
Pegloticase MOA coverts UA to an inactive metabolite allantoin that can be easily excreted
Who is pegloticase reserved for severe refractory gout
which xanthine oxidase inhibitor causes increase in LFTs Febuxostat ( Uloric)
Both xanthine oxidase inhibitors have warning for hepatototoxicity SKin rash ( TEN, SJS, DRESS)
Probenacid can increase the levels of what other drug beta lactam levels
Pegloticase Krystexxa
Pegloticase formulation IV
Krystexxa has boxed warning for anaphylactic reaction:
How to prevent Krystexxa anaphylactic reaction premedicate with antihistmaine and steroid
Pegloticase is contraindicated with G6PD deficiency
which drugs should not be used with febuxostat Mercaptopurine and azathiopurine
Pegloticase should be avoaided with xanthine oxidase inhibitors and probenacid
colchincine side effects Diarrhea, nausea, myopathy, neuropathy
Colchincine should be avoided with strong CYP34 inhibitor and pgp inhibitors
Created by: annaiibarrera
 

 



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