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Gout
Question | Answer |
---|---|
Colchicine | Colcrys Gloperba Mitigare |
Colchicine dosing | two 0.6 mg tablets followed by 1(0.6 mg) tablet in 1 hour |
Do not exceed how much colchicine in 1 hour | 1.8 mg in 1 hr ` |
When should youstart colchicine | within 36 hours of sympton onset |
When can you resume prophylaxis after treatment with colchicine | 12 hrs after treatment |
naproxen | Aleve |
Indomethacin | indocin |
Celecoxib | Celebrex |
How are steriods given | IV, IM, PO, intra-articular or adrencorticotropic hormone |
Methylpresnisionol | Medrol Solu-Medrol |
Methprednisolone dosing | intra-articular if 1-2 large joimts involved |
Canakinumab | llaris |
Canakinumab MOA | interleukin 1 anatagonist |
What must be done prior to canakinumab | TB testing |
what must be avoided with canakinumab | live vaccines |
Allopurinol | Zyloprim Aloprim |
Allopurinol MOX | Xanthine oxidase inhibitor |
Febuxostat | Uloric |
Frbuxostat MOA | Xanthine Oxidase inhibitor |
Xanthine Oxidase inhibitor | block xanthine oxidase enzyme to decrease uric acid production |
If taking allopurinol pt should be screened for what gnee | HLA-B 5801 allel |
UA target level | < 6 |
Probenacid MOA | inhibits reabsorption of UA in the proximal tubule |
Probenacid is | Uricosuric |
Pegloticase is | recombinant uricase enzyme |
Pegloticase MOA | coverts UA to an inactive metabolite allantoin that can be easily excreted |
Who is pegloticase reserved for | severe refractory gout |
which xanthine oxidase inhibitor causes increase in LFTs | Febuxostat ( Uloric) |
Both xanthine oxidase inhibitors have warning for | hepatototoxicity SKin rash ( TEN, SJS, DRESS) |
Probenacid can increase the levels of what other drug | beta lactam levels |
Pegloticase | Krystexxa |
Pegloticase formulation | IV |
Krystexxa has boxed warning for | anaphylactic reaction: |
How to prevent Krystexxa anaphylactic reaction | premedicate with antihistmaine and steroid |
Pegloticase is contraindicated with | G6PD deficiency |
which drugs should not be used with febuxostat | Mercaptopurine and azathiopurine |
Pegloticase should be avoaided with | xanthine oxidase inhibitors and probenacid |
colchincine side effects | Diarrhea, nausea, myopathy, neuropathy |
Colchincine should be avoided with | strong CYP34 inhibitor and pgp inhibitors |