Lecture 6 Word Scramble
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| Question | Answer |
| What are miRNAs? | 21-30 bp; unstructured transcripts |
| What are siRNAs? | bound by specific proteins and target them to corresponding mRNA |
| What is the miRNA function in animal cells? | affect translation; base pairing to the C-terminal |
| What is the miRNA function in plant cells? | affect message stability |
| What is the siRNA function? | base pairing to target RNA; targets for cleavage |
| What is the function of Dicer? | degrade dsRNAs into short lengths, creating siRNAs |
| What is the function of Argonaut (Ago)? | cleavage of mRNA in RISC |
| What is RISC? | RNA-induced silencing machinery |
| What is RDRP? | RNA-directed RNA Polymerase; uses RNA as a template to synthesize more RNA |
| What is the mechanism for RNAi activation, PTGS? | RDRP amplifies signal, Dicer processes dsRNA, loads into Ago complex RISC, RISC targets mRNA with the siRNA and cleaves it |
| What is Drosha? | dsRNA nuclease specific to miRNA; cuts miRNA into a hairpin |
| Which small RNA has to be a perfect match to target? | siRNA |
| Which small RNA does not have to be a perfect match to target? | miRNA |
| What is RITS? | modified Argonaut/RISC complex; associated with heterochromatin formation |
| What is CRISPR-CAS? | targeting system from bacteria; allows programming of enzyme with targeting RNA that directs toward invading DNA using PAM |
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