Pharm '14 - Block 1 Word Scramble
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Question | Answer |
which 2 classes of drugs block acid secretion | H2 blockers and PPI |
weak bases that chemically neutralize acid | calcium carbonate |
binds to mucosa and inhibits pepsin-catalyzed hydrolysis of mucosal proteins, ie builds up a protective wall | sulcrafate |
prostaglandin that increases bicarb and mucus from epithelial cells, inhibits acid from parietal cells | misoprostol |
locally acting, secretion reducing, topical that binds toxins and is anti-diarrheal | pepto |
competitive antagonists at H2 receptors on parietal cells; inhibit meal secretions and basal secretions | H2 blockers |
binds and irreversibly blocks ATP-dependent proton pump in parietal cell | PPI |
which class+abx eliminates H. pylori | H2 blockers and PPI |
relieves stress ulcers, ZE ulcers, GERD, dyspepsia, PUD | H2 blockers |
PUD, GERD, ZE, may reduce gastric acid for 4-6 weeks | PPI |
best 2 options for reducing acid in the elderly | ranitidine and calcium carbonate |
PUD treatment in pts who cannot tolerate H2 or PPI | sulcrafate |
prevents ulcers in pts taking NSAIDs | misoprostol |
X varicella vaccine, MMRV, pts <20 w/flu, or if febrile | pepto |
may cause Reye's syndrome | pepto |
may cause early uterine contractions and not good w/CVD | misoprostol |
requires acidic stomach for activation | sulcrafate and omeprazole |
do not combine ___ with sulcrafate | antacids |
AlOH causes____ | constipation |
MgOH causes____ | diarrhea |
Rolaids may increase the absorption of meds like ____ | Ldopa, weak bases |
BB increased hip fractures in the elderly | PPI |
interacts with atazanavir, antacids, and is CYP450 | omeprazole |
first line agents to reduce gastric acid, suppress 90% acid | PPI |
prokinetic agent | metoclopramide |
anti-diarrheals | lomotil, immodium, pepto |
stimulates smooth muscle in the GI, promotes ACh release and blocks DA | metoclopramide |
bulk laxative that increases mass | psyllium |
surfactant stool softener | colace |
osmotic laxative | magnesium hydroxide and miralax |
poorly absorbed molecules draw in water, increasing volume | magnesium hydroxide and miralax |
preop for GI surgery | dulcolax |
activates GI opiod receptors, decreases ACh release | lomotil and immodium |
used for hypomotility, gastroparesis, intractable hiccup, antiemetic | metoclopramide |
X seizures, GI obstruction, GI hemorrhage | metoclopramide |
interacts with MAOI and may cause HTN crisis | metoclopramide |
H2 blockers | ranitidine and famotidine |
PPIs | omeprazole and esomeprazole |
antacids | calcium carbonate |
mucosal protective agents | sulcrafate, misoprostol, pepto |
5HT3 receptor antagonist, blocks afferent signals to CTZ | zofran |
D2 blocker/anti-emetic and anti-psychotic | compazine |
NK1 antagonist | emend |
cannaboid receptor agonist | marinol |
blocks vestibular component of vomit reflex | dramamine |
anticholinergic, antiemetic, antidyskinetic | scopalamine |
which 2 drugs are combined to treat chemo nausea | zofran+emend |
chemo sickness and AIDS anorexia | marinol |
motion sickness and parkinsons | scopalamine |
which antiemetic has the most drug interactions? | compazine |
a CYP450 and interacts with benzos | emend |
stimulant laxative | dulcolax |
opiates | morphine, heroin, methadone, buprenorphine |
CNS depressants | alcohol, naltrexone, benzos |
inhalents | toluene |
CNS stimulants | methamphetamines, methylphenidate, nicotine, cocaine |
hallucinogens | LSD, PCP, THC, XTC |
releases NE and DA, inhibits MAO | methamphetamines |
ACh mediator of SNS and PSNS | nicotine |
inhibits reuptake of DA and NE | cocaine |
related to ketamin, once used as a vet tranq | PCP |
binds in CNS @ CB1, binds in PNS @ CB2 | THC |
semi-synthetic partial opiod used to treat opiod addiction | buprenorphine |
inhibits NMDA glutamate receptor, penetrates BBB and placenta | alcohol |
used in mgmt of EtOH and opiod addiction | naltrexone |
CNS depressant used to stabilize alcoholics | benzos |
stimulates androgen receptors | steroids |
toluene is toxic to which organs | liver, kidney, brain |
toluene cause of death | sudden sniffing death |
used for euphoria, but tolerance rises rapidly-->respiratory depression and pinpoint pupils | morphine and heroin |
which organs are damaged with alcohol? | liver and brain |
which drug has a cross tolerance with EtOH | benzos |
abused for feelings of oneness with the universe | hallucinogens |
abused for euphoria, exhilaration, confidence, decreased fatigue | CNS stimulants |
how does nicotine damage the heart? | sympathoactivation without physical exertion "silent stress" |
what do you give to detox cocaine | TA-CD vaccine |
how do you treat PCP withdrawl | prevent injury reduce stimuli ameliorate psychosis with drugs |
SE of XTC | bruxism, hypothermia, dehydration |
what happens if a depressed person takes methamphetamines? | suicide |
antidepressant and sex dysfunction | 5HT1 stimulation |
anxiety and sex dysfunction | 5HT2 stimulation |
GI motility, nausea, increased memory | 5HT3 stimulation |
increased BP | NE reuptake inhibitor |
antidepressant, activation, psychosis, motivation | DA reuptake inhibitor |
constipation and dry mucous membranes | muscarinic antagonists |
sedation and weight gain | H1 antagonist |
orthostatic hypotension and reflex tachy | alpha1 antagonism |
increased NE levels | alpha2 autoreceptor antagonism |
increased 5HT (mirtazapine) | alpha2 heteroreceptor antagonism |
which drug is a triazolopyridine | trazadone (also SARI) |
what labs should you draw with lithium? | Pregnancy Thyroid Blood EKG Electrolytes Renal function |
which drug is similar to lithium, but with faster onset | carbemazepine |
which antipsychotics are safe in 1st trimester | haloperidol |
which antipsychotocs are safe in 2nd and 3rd trimesters? | atypicals |
BB for clozapine | seizures and agranulocytosis |
what should clozapine pts report signs of? | fever, weakness, sore throat |
EPS are indicative of ___ | high potency typicals |
sedation is seen with which receptor? | histamine |
what are the atypicals? | chlorpromazine, fluphenazine, haloperidol |
SE for typicals? | seizure photosensitivity lactation weight gain temp regulation issues SCD |
which drugs may cause akathisia/motor restlessness, parkinsonism | fluphenazine, haloperidol |
which drug causes low EPS sx and dystonia pseudoparkinsonism, tachy | chlorpromazine |
which drugs are high potency | fluphenazine and haloperidol |
available in depot? | flu and hal |
which drug is similar to clozapine | zyprexa |
used for depression maintenance in combo with fluoxitine | zyprexa |
gives EPS in doses >6mg | risperdal |
which drug causes cataracts | seroquel |
which atypical has the weakest adverse effects | ziprasidone |
causes HA/n/v akathesia | abilify |
causes heavy sedation, dystonia, pseudoparkinsons | clozapine |
causes somnolence, akathesia, high glucose, EPS, prolactin, Weight LOSS | lurasidone |
which atypicals are approved for maintenance of depression (4) | zyprexa, risperdal, seroquel, abilify |
influences negative sx, and used in neuroleptics for + sx | ziprasidone |
used for tx resistant schizophrenia | clozapine |
used for acute schizo and acute mania with bipolar | asenapine |
BB for all atypicals | elderly with dementia @increased risk of death and high glucose |
which drug prolongs QT | ziprasidone |
prescribers must register | clozapine |
must get CBC before initiation | clozapine |
may increase suicide ideations | abilify |
take with food | ziprasidone and lurasidone |
"me too" drug that can be used when other neuroleptics d/ced due to EPS | clozapine |
+signs | delusions hallucinations disorganized speech behavior disturbance |
- signs | social isolation flat affect poverty of speech anhedonia |
may cause weight gain, sex dysfunction, leukopenia, tremor, orthostatic hypotension | phenelzine |
may cause insomnia, decreased libido, nausea, diarrhea, weight loss, poor appetite (class) | SSRI and SNRI |
don't use with NSAIDs or other anti-platelets | SSRI |
take with food | vilazodone |
don't use with tobacco, warfarin, SSRIs, St Johns Wort, or MAOIs | amitriptylline |
what drugs cause hypertensive crisis | phenelzine+tyramine or stimulants or Ldopa or pseudoephidrine |
what causes serotonin syndrome | phenelzine +SSRI or TCA |
what class has SE of HTN crisis and serotonin syndrome? | MAOI |
BB cardiac toxicity | amitriptylline |
may cause anorgasmia, anorexia, impotency | SSRI and SNRI |
longest duration of action for SSRIs | fluoxetine (prozac) |
potent and selective serotonin and NE reuptake inhibitor | pristiq |
inhibits reuptake of serotonin and NE | amitriptylline |
deposits into lipid membranes | amitriptylline |
5HT1 receptor partial agonist | SSRI |
inhibits 5HT and NE reuptake, weak reuptake DA | SNRI |
weak block of DA | buproprion |
serotonin 2 antagonist | trazodone |
causes increased cholesterol, proteinuria, high blood pressure | pristiq |
causes sedation, weight gain, neutropenia | mirtazapine |
X in hx of seizures, bulemia | buproprion |
causes priapism | trazodone |
decreases NE release and increases serotonin synthesis | lithium |
histone deacetylase inhibitor | VPA |
sodium channel blocker | lamotrigine |
tricyclic that limits electrical action | carbamazepine |
used for acute mania, acute depression, bipolar maintenance | lithium |
used for acute mania, mixed, maintenance | VPA |
long term maintenance of adults with bipolar | lamotrigine |
used for acute and mixed mania (bipolar) | carbamazepine |
may cause tremor, hair loss, hepatotox | VPA |
wt gain, polydipsia, polyuria, hypothyroid, arrythmias, ataxia | lithium |
causes rash if rushed | lamotrigine |
causes SJS, lots skins stuffs, anti-diuretic, ataxia, diplopia | carbamazepine |
may become toxic if pt is dehydrated | lithium |
don't use with diuretics, NSAIDs, ACEi, ARBs | lithium |
don't use with HIV meds | VPA |
inhibits CYP450, so dont use with warfarin | VPA and vilazodone |
what are the mood stabilizers? | lithium, VPA, lamotrigine, carbamazepine |
what is the indication for SNRIs? | severe depression when increased drive is desired |
are tricyclics or SSRI more potent for depression? | tricyclics |
do tricyclics or SSRIs have more SE? | tricyclics |
which drug is ok to breastfeed? | amitriptylline |
what should you monitor with pristiq? | BP and urine analysis |
all Anti-Depressants cause weight gain except.... | SSRI, SNRI, buproprion |
most teratogenic? | lithium and VPA and carbamazepine |
non-selective ß-blocker causes splanchnic vasoconstriction | nadolol |
decreases intestinal NH3 by acting against urease producing bacteria | neomycin sulfate |
somatostatin analog; inhibits serotonin, gastrin, insulin, glucagon and alters mesenteric/sphlanchnic blood flow promoting hemostasis | octreotide |
inhibits binding of aldosterone to receptor | spironolactone |
inhibits sodium-potassium symport in ascending limb | furosemide |
used in cirrhosis induced hepatic encephalopathy | neomycin sulfate |
used for bleeding esophageal varicies | octreotide and nadolol |
used for cirrhosis induced edema | spironolactone and furosemide |
causes nephro and ototoxicity | neomycin sulfate |
causes gynecomastia | spironolactone |
monitor B12 levels, cholelithiasis, hypothyroidism, anemia | octreotide |
avoid NSAIDs | spironolactone and furosemide |
aides in hydrolysis of fats, proteins and starches | pancrelipase |
interacts with iron salts, iron, multivitamins | pancrelipase |
monitor growth and development | pancrelipase |
titrate "low and go slow" | pancrelipase |
how do you monitor the effectivity of neomycin sulfate? | clinical improvement |
used after removal of >5L paracentesis | albumin 25% |
how long for diuretics to reach "steady state"? and how often should you adjust dose? | 3-5 days |
don't use with DM or renal impairment | octreotide |
which 2 cirrhosis drugs are pricy? | octreotide and albumin 25% |
treats constipation, eliminates poisons | miralax |
treats hepatic encephalopathy and constipation | lactulose |
used for women with constipation IBS | amitiza |
relieves short-term constipation IBS | zelnorm (tegaserod) |
women with diarrhea IBS | alosetron |
relieves abdominal pain and bloating in pts w/o constipation | rifaximin |
relieves abdominal pain due to smooth muscle relaxation and anti-cholinergic effects | dicyclomine (bentyl) |
X with GI obstruction or appendicitis | miralax and amitiza |
X with low galactose diet | lactulose |
X crohns, UC, constipated patients | alosetron |
don't use with other anticholinergics or during lactation | dicyclomine (bentyl) |
must be taken BID q12 h | alosetron |
dyspnea with first dose | amitiza |
may cause electrolyte imbalances | miralax and lactulose |
treats HBV | entecavir, adefovir, lamivudine |
treats HCV | ribavirin |
X in pregnancy (men too), anemia, ESRD | ribavirin |
X lactation and kids<12 | adefovir |
causes dose dependent hemolytic anemia | ribavirin |
may cause exacerbation of hepatitis w/in 12 weeks of stopping med | adefovir |
causes lactic acidosis, hepatic steatosis, pancreatitis, peripheral neuropathy | lamivudine |
common SE is flu-like syndrome | interferons |
HBV monotherapy and HCV +ribavirin | interferons |
Xhepatic decompensation, autoimmune dz, hx of cardiac arrhythmias | interferons |
interacts with psych meds and zidovudine | interferon alpha 2a |
which interferon has a longer half life? | alpha 2a |
BB lactic acidosis, hepatomegaly, steatosis | lamivudine |
BB hep B exacerbation, HIV resistance, hepatomegaly | adefovir |
BB hx of anemia | ribavirin |
take with food | ribavirin |
X acute HSV, vaccines, fungal infections | prednisolone |
used for alcholic liver disease and alcoholic hepatitis | prednisolone |
used in alcoholic hepatitis in pts who are not steroid candidates | pentoxifylline |
non-steroidal phosphodiesterase inhibitor | pentoxifylline |
may decrease mortality by decreasing hepatorenal syndrome | pentoxifylline |
which anti-viral is CYP450 | ribavirin |
arthralgia, dyspepsia, anemia | sulfasalazine |
increased LFTs, infectious complications, lymphoma | azathioprine |
hypertrichosis, hyperglycemia, hypertriglycerides, increased infection and lymphoma | cyclosporin |
interacts with cardiac glycosides and heparin | sulfasalazine |
decreased effectivity with antacids, PPI, H2 blockers | mesalamine |
increased bleeding risk with heparin (class) | aminosalicyclates |
take with food (2) | sulfasalazine and ribavirin |
supplement with folic acid | sulfasalazine and methotrexate |
BB warning for malignancy | azathioprine |
allopurinol increases risk for toxicity | azathioprine |
contraindicated with antibiotics, anti-convulsants, allopurinols, CCB, grapefruit juice, statins...CYP3A4 pathway | cyclosporin |
category X (2) | methotrexate and cipro |
primarily UC | sulfasalazine |
distal UC and mild-mod Crohns | mesalamine |
steroid sparing in IBD | azathioprine |
Crohns>UC for mod-severe maintenance | methotrexate |
severe refractory UC | cyclosporin |
mild-moderate Crohns, maintain UC remission | budesonide |
IBD that fails other treatments | inflixamab |
may cause infusion reaction, sepsis, serum sickness, TB reactivation | inflixamab |
BB for UC | natalizumab |
reactivates JCV | natalizumab |
used for refractory Crohns disease | ustekinumab |
causes pruritis, injection site erythema, increased malignancy risk | ustekumab |
don't use these 2 with other immune suppressants or vaccines | natalizumab and ustekinumab |
may cause tendon rupture | cipro |
do not use with warfarin (2) | cipro and flagyl |
alcohol intolerance | flagyl |
only used for crohns | natalizumab |
used for refractory crohns | ustekinumab |
1st generation ASA that interferes with prostaglandin synthesis | sulfasalazine |
inhibits dihydrofolate reductase-->death of T-lymphocytes | methotrexate |
calcineurin inhibitor, inhibits Tcell signal transduction | cyclosporin |
inhibits production of IL1, TNF and inflammation molecules | budesonide |
chimeric monoclonal antibody and anti-TNF | infliximab |
DNA gyrase inhibitor | cipro |
inhibits DNA synthesis, bactericidal | metronizadole |
aldehyde dehydrogenase inhibitor | disulfiram |
do not use for aerobic bacteria | metronizadole |
do not take with heparin | aminosalicyclates |
AE elevated LFTs, agranulocytosis | mirtazapine |
SNRIs | effexor, cymbalta and pristiq |
SSRIs | prozac, zoloft, lexapro, and viibryd |
MAOIs | phenelzine (nardil) |
mesolimbic pathway | causes + symptoms |
mesocortical pathway | cuases - symptoms |
nigrostriatal pathway | inhibition causes EPS typicals inhibit atypicals do NOT inhibit |
tuberoinfundibular pathway | inhibition elevates serum prolactin |
direct acting antivirals | boceprevir and telaprevir |
treats naive and experienced Hep C | boceprevir and telaprevir |
must be given with PegIFN and wt based ribavirin | boceprevir and telaprevir |
genotype 1 is wt based doseing, 2 and 3 are fixed | ribavirin |
alpha 1 antagonist | orthostatic hypotension, reflex tachy |
alpha 2 Heteroreceptor antagonist | increased 5HT |
alpha 2 autoreceptor antagonist | increased NE |
5HT1 (+) | AAAS (antidepressant, anciety, addiction tx, sexual dysfxn) |
5HT2 (+) | AGIS (anxiety, GI motility, improved behavior/sleep, sexual dysfxn) |
5HT3 (+) | GAIN (GI motility, anxiety, improved memory, nausea) |
NE reuptake (-) | AAB (antidpressant, activatino, increased BP) |
Dopamine reuptake (-) | AAMP (antidepressant, activation, motivation, phychosis) |
Muscarinic (-) | CDD (constipation, dry mouth, dry eyes) |
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