CVS Pharmacology Test
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| A. HypotensionB. ventricular myocytes in response to stretchC. Digitalis
PimobendanD. Accumulation of cAMP and cGMP leading to positive inotropic activity and peripheral vasodilationE. Improve cardiac performance at rest and during exercise
Relieve symptoms
Improve myocardial efficiency
Improve quality of life (particularly symptom-free and effort tolerance)
Improve patient survivalF. G.I.T: Anorexia, nausea, cramping, diarrhea
Visual: Xanthopsia, color blindness
Neurologic: Malaise, confusion, depression, vertigo
Cardiac: bradycardia, Palpitations, syncope, arrhythmias, AV node block, VT
Interactions G. Intermittently (IV) in CCHFH. Negative inotropic
Not useful in refractory HF
Slowing of HR, decreased cardiac work and consequently decreased myocardial O2 consumption and enhanced efficiency lessen the frequency of ischemic events and arrhythmiasI. Arrhythmias
Ischemic changesJ. Stimulation of DA1 receptors leading to renal vasodilation and improved renal functionK. Diuretics
Aldosterone receptor antagonists
Angiotensin-converting enzyme inhibitors
Angiotensin receptor blockers
Beta blockers
Cardiac glycosides
Vasodilators
Beta agonists
Bipyridines
Natriuretic peptide L. Through resensitization of the down-regulated receptorM. Salt restriction
Treat the cause
Moderate exercise
Heart TransplantationN. Reduction in preload and afterloadO. In acute heart failure and for short periods in CCHFP. Only useful in CCHF with supraventricular arrhythmia
Might decrease morbidity Q. DOC in HF
No tolerance
Retard progression of HF
Decrease arrhythmias
Only drugs which decrease mortality, but only when the highest tolerated doses are usedR. Nitroprusside S. Losartan
Candesartan
Valsartan
Irbesartan(Approvel)
Telmisartan(Micardis)T. All increase myocardial oxygen consumption, may be used (IV) for short term or in acute heart failure |
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Ulaisl
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