First AID Antiarrhythmic Drugs
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| show | NaB the Long Cab: I=Na blockers, II=Beta blockers, III=Long refractory period and QT interval - K+ block, IV=Ca2+ channel blockers
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| show | Local antesthetics. Slow or block conduction (especially in depolarized cells). Decrease the slope of phase 4 depolarization and increase threshold for firing in abnormal pacemaker cells.
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| Drugs of Class IA | show 🗑
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| show | Slow phase 0. Affect whole heart. Increase AP duration, Increase effective refractory period (ERP), and increase QT interval.
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| Indications for Class IA | show 🗑
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| show | Quinidine
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| show | Headache, tinnitus and dizziness
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| What drug reduces the renal elimination of digoxin? | show 🗑
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| N-acetylprocainamide is an active metabolite | show 🗑
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| Can cause a reversible SLE-like syndrome | show 🗑
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| SE common to all Class IA | show 🗑
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| show | Mexiletine, Lidocaine, Tocainide (Mitra Loves Tom)
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| show | Shorten phase 3, Affect ventricles. Unlike class 1A - these decrease AP duration (and thus ERP). Affect ischemic or depolarized Purkinje and ventricular tissue.
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| General use of Class IB | show 🗑
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| General side effects of Class IB | show 🗑
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| show | Flecainide, encainide, propafenone (Follwing Eating Poop)
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| show | Markedly slow phase 0 (as all class 1 antiarrhythmics do). Affects atria. Has NO effect on AP duration
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| General use of Class IC | show 🗑
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| show | Proarrhythmic - especially post-MI (contraindicated). Significantly prolongs refractory period in AV node
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| show | Class IA antiarrhythmics
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| Useful in acute ventricular arrhythmias (especially post MI) and in digitalis-induced arrhythmias | show 🗑
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| show | Class IC antiarrhythmics
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| show | Class IA = Increase AP duration. Class IB = Decrease AP duration, Class IC = don't effect AP duration
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| Area of heart affected by Class I antiarrhythmics | show 🗑
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| Class II antiarrhythmics | show 🗑
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| General actions of Class II | show 🗑
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| Indications for Class II | show 🗑
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| Side efx of Beta-blockers | show 🗑
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| CI of Beta blockers | show 🗑
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| show | "A Bodygouar is Strong" (Amiodarone, Bretylium, Ibutilide, Sotalol)
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| General action of Class III | show 🗑
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| SE: Torsades des pointes, excessive B-block | show 🗑
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| show | All can cause torsades des pointes (b/c inc QT interval)
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| show | Pulmonary fibrosis, hepatotoxicity, Hypo/Hyperthyroidism. Amiodarone inhibits CYP3A4 (so don't use w/warfarin)
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| show | Calcium channel blockers
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| General mech of Class IV | show 🗑
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| show | Flushing, Constipation, Edema. Can also cause heart block, or torsades de pointes.
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| show | Adenosine
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| show | K+
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| Effective in torsades de pointes and digoxin toxicity | show 🗑
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