MCPHS Infec Diseases Exam 2 P2s
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| show | Lyme: Acute Inflamitory Bacterium Borrelia burgdorferi Spirochete
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| Lyme: Endemic ? | show 🗑
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| show | Lyme: 75% Bulls Eye Rash in 2-30 days, Fatigue, Chills, Fever, HA, Joint Ache, Lymph (Diseminated/Untreated: Loss of Musscle Tone, Bell's Palsy, HA, Meningitis, Shooting Pains at night, Joint Pain, Heart Palpitations, Dizziness, Arthritis, Joints Swell
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| show | Deer Tick (NE) Blacklegged Tick (West Coast) USA Live 2 yrs: Larvae, Nymph Adult
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| Lyme: Diagnosis? | show 🗑
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| show | Antibiotics: oral/IV responds well if early tx. Doxy, Amox, Ceftriaxone (multi-drug for severe cases)
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| Lyme: Prevention? | show 🗑
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| show | SARS: Coronavirus (Palm Civet animal virus 1:1255 AA change to bind to human ACE2 Receptor)
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| SARS: Nov 2002 - July 2003 (History)? | show 🗑
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| show | SARS: incubation 2-14d, fever >100.4, HA, Body Aches, Mild Resp Onset, Diarrhea 10-20%, 2-7d of onset Non-productive cough, then most develop Pneumonia,
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| show | SARS: Person-Person, Cough/Sneeze/Fomites (No trans from Asymptomatic case), Most Contagious Second Wk of Illness, Limit Human Contact 10 d after fever & Respiratory disappear
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| SARS: Epidemiology? | show 🗑
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| SARS: Treatment? | show 🗑
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| SARS: Tests? | show 🗑
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| show | SARS: Min Travel, avoid contact 10d after s&s gone, Hygiene, Masks, goggles, gloves
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| SARS: Dynamics of Spread? | show 🗑
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| show | Avian Flu: ss-RNA 8-Segment Virus, Mutates Freq. Drift Birds, Pigs = mix Antigenic Shift 1918 Spanish Flu, recent H5N1 Drift Bird-Human, Ducks Endemic Asia
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| Avian Flu: History? | show 🗑
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| Types of Influenza? | show 🗑
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| Type A Viruses? | show 🗑
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| show | 97' HK (18/6 Infec/deid), Feb. 2003-04' SAR family father, son, daughter HK traveled to S. China, 2 died, (vietnam 22/15, Thailand 12/8). World Totals 03-04': 251/148
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| show | Avian: Density of infected poultry, Freq. of Human Exposure, Duck Fecal in yards, Viral Pathogen Contact/aerosol/fomite, bird-human, no Human-Human (no reassortment)
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| show | Endemic Dom/Wild Birds SE Asia, Virus in Birds more Virulent, Asymptomatic Ducks, Expanding host range to Cats/tigers, 04' virus survives longer in environment, no H5 immunity in Humans
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| Good News about Avian Flu? | show 🗑
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| Hantavirus: First Outbreak? | show 🗑
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| show | June - Aug 93' trapped Deer Mice, 30% Infected, Population 10x's norm, excess snow, increase in food sup., Virus Named Muerto Canyon Virus (death valley), renamed: "Sin Nombre Virus" (SNV)
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| Hantavirus Pulmonary Syndrome (HPS)? | show 🗑
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| Huntavirus stats? | show 🗑
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| Huntavirus: Transmission? | show 🗑
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| show | Huntavirus: Bunyaviridae Family, 5 Genera, 250 Species (Hemorrhagic Fever w/ Renal Failure is Close relative to Huntavirus Pulmonary Syndrome), RNA virus, Budding, Persist n Host, Lipid Membrane, Others are Transmitted Via Arthropods, but Hunta by rodents
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| show | LA, FL, NY, Argentina, Brazil, Chile, Paraguay, Uraguay (Dif. Strains Co-evolved in dif Rodents) Sin Nombre, Black River, NY strains...
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| show | Req's beta-3 Integrins w/virus glycoproteins to cause vascular integrity disruption making capilaries more permeable and disrupting arteriole vaso-constrictions/dilation problems, binds to platelet receptors affecting clotting factors
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| show | Hantavirus Patho Immune response caused by Viral epitopes on host cells triggers cytotoxic T-Cell attack on host tissues
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| Huntavirus: Detected by? | show 🗑
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| Huntavirus: Biowarfare? | show 🗑
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| show | Ernest Duschesne Pen 1896, Alexander Fleming Pen Rediscovered 1928, WWII widely avail, 47' S.Aureus Resistant to Penicillin, 67' Pen-Resist. Streptococcus Pneumoniae & Gonorrhea (SE Asia Prostitutes), 76' GI's to USA, 83' Hos-aq'd Pen-Res Entro, 87' VREs
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| show | VREs, MRSAs, nearly all Staph Aureus are Pen resistant, Vancomycin is drug of choice for Staph Aureus (some are now Vanco-Resistant)
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| show | 2 M Nosocomial Infections Yr. USA, 90K Deaths Yr USA, >70% bacteria causing these infections are Resistant to Commonly used Antibiotics
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| show | 85' 6M Rxs for Sinusitis, 15 M for Inner Ear: 92' 13 M Sinusitis & 23 M for Inner Ear Infections. Expanding Population of Immunocomp Hosts, Pts living longer, getting sicker, dieing more slowly, Incr Invasive Procedures, Inappro Use of Med (viral/animal)
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| Antibiotic Resistant Org/diseases? | show 🗑
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| show | Adapts or Dies off, Mutation Rates unchecked/uncorrected viral drift, fast growth rate, subtherapeutic dosing, poor adherence to Tx, too few drugs (Ehrlich 1913 Hit them hard/early, resistance w/single point mutation eg. TB)
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| 4 Mech. for Tx Failure? | show 🗑
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| show | Restricted Uptake/Efflux (Pumping), Drug Inactivation (Enzymatic Alt of Drug, Drug Sequestering by pro bind, Enzymatic Degradation of Drug), Mutations in Targets (Mod targets, Over Prod. target, Metabolic Bypass of targeted Pathway)
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| 3 Mech of Resistance Occurs by ? | show 🗑
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| Ways to combat Resistance? | show 🗑
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| show | 400-190 BC Archers/Fecal, Persain/Greek Lit/Wells, Hannibal Vessel Snakes vs Pergamon, 1346 Siege Caffa Tartar hurl Plague, 1710 Russian plag vs sweeds n Estonia, 18th Frnch/Indn War Brits Smallpox Blankets
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| show | WWI Germans/Anthrax/Glanders/Cholera/Wheat Fungus, 25' Geneva Protocal 108 Nat'n Proh-Use, WWII Unit 731 Manchuria/Janpanese >3K Plag/Anthrx/Syphilis, 42' US War Resch Srvs Anthrax/Botulinum Tox (stockpile 44'), 72' Biological Weapons Conventn 144 Nat'ns
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| Bioweapons: Rogue Nations/groups? | show 🗑
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