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show | multicellular
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The maintenance of a constant environment in a cell is called ___________. | show 🗑
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show | environmental
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show | regulation
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Eukaryotic cell mRNA transcripts tend to be very ______ and can remain in the cell for hours. | show 🗑
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show | enhancer sequences within the DNA.
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show | major groove of the DNA helix.
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9. Vertebrate cells apparently possess a protein that by binding to clusters of 5-methylcytosine ensures that the bound gene will stay in the "off" position. This control on the role of gene regulation is a result of | show 🗑
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10. Regulatory proteins shut off transcription by binding to a site immediately in front of the promoter and often even overlapping the promotor. This site is referred to as the | show 🗑
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show | nucleosomes
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show | homeostasis
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show | specific transcription factors.
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show | transcriptional control.
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15. A nucleosome contains ____ histones within its core | show 🗑
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16. The basic tool of genetic regulation is the ability of certain proteins to bind to specific | show 🗑
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show | once a gene is turned off, it will remain off.
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show | In bacteria it allows them to replicate without control.
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show | promoter.
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20. Small RNAs, once thought to be of no importance in gene expression contain | show 🗑
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show | double stranded RNA interference with mRNA.
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22. Proteins that bind to regulatory sequences have shapes that fit into the | show 🗑
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23. The DNA-binding proteins of almost all regulatory proteins employ one of a small set of shapes that enable them to fit into the major groove of DNA. These shapes are called | show 🗑
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24. All of the following are examples of shapes in regulatory proteins which are used to bind to DNA except the | show 🗑
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show | repressor.
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show | activator.
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27. A bacterial gene regulatory system is likely to have all of the following except | show 🗑
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28. Small RNAs can regulate gene expression. One type, called micro RNA (miRNA), acts by binding directly to | show 🗑
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29. The lac regulatory system is important to bacteria because the sugar lactose | show 🗑
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30. A well-understood transcriptional activator of E. coli, which initiates the transcription of genes in nonglucose environments, is called | show 🗑
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31. In eukaryotes, specific transcription factors have two distinct domains: | show 🗑
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show | RNA polymerase must have access to the DNA double helix and also must be capable of binding to the gene's promoter.
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show | entering the major groove of the DNA and reading the nucleotide base pairs.
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show | inserting DNA-binding motifs into the major groove of the double helix where the edges of the nitrogen bases protrude.
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show | trp operon.
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show | lac operon.
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show | have their transcription occurring in the nucleus and translation in the cytoplasm.
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show | CAP molecule is bound to cAMP.
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show | The primary transcript is a faithful copy of the entire gene including exons and introns.
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40. One of the DNA-binding motifs that contains a nearly identical sequence of 60 amino acids in many eukaryotic organisms is known as the | show 🗑
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show | helix-turn-helix.
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show | repressor
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show | CAP
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show | operon
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show | operator
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46. A site at the 5' end of a gene to which RNA polymerase attaches to initiate transcription. | show 🗑
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show | homeodomain
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show | inducer.
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49. The lactose analog isopropyl-β-D-thio-galactoside (IPTG) is often used to regulate gene expression systems in bacteria. IPTG does not act as a substrate for β-galactosidase, but can bind to, and inactivate, repressor. In this case, IPTG serves as a(n) | show 🗑
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50. The main form of glucose repression of the lac operon is | show 🗑
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51. Which of the following statements regarding control of the lac operon and lactose utilization in bacteria is false? | show 🗑
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52. Mutations in the -35 region of the trp operon would | show 🗑
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show | the operon is OFF in the absence of its regulatory protein.
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54. In eukaryotes, the binding of TFIID is followed by the binding of a number of other general transcription factors. Which of the following lists the correct order of binding of these factors? | show 🗑
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55. Your research project involves the characterization of a recently identified transcription factor. As part of your project, you want to determine if this transcription factor binds directly to any of the general transcription factors. Unfortunately, h | show 🗑
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show | primarily upstream of the promoter; distance from the promoter does not matter.
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show | coactivator.
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show | TATA-binding protein TBP and TAFs.
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59. Which of the following statements regarding the eukaryotic transcription initiation complex is false? | show 🗑
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show | chromatin remodeling.
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61. DNA methylation is the only known natural modification of DNA. It affects | show 🗑
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show | be looking at a region of inactive chromatin.
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show | allow us to turn specific genes on or off.
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show | Use RNA interference to prevent mRNA translation.
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show | miRNA and siRNA.
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66. The gene encoding apolipoprotein B exists in two isoforms, APOB100 and APOB48. These two forms are produced as a result of | show 🗑
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67. Production of the iron-storing protein ferritin is regulated by aconitase, which binds to a 30-nucleotide sequence at the beginning of the ferritin mRNA and interferes with ribosome binding. Aconitase is a | show 🗑
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show | Ubiquitination of a targeted protein requires only one molecule of ATP.
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69. What is the difference between a gene that is derepressed and one that is induced? | show 🗑
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