Heavy metal
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each of the black spaces below before clicking
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| Most heavy metal toxicities occur due to | interaction with sulfhydryl groups
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| Chelators are compound with _ electronegative groups’ | 2 or more
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| Chelators function as _ | chemical antagonists
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| Acute lead poising typically affects which system | CNS
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| Acute lead poising treated with | chelation
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| Chronic lead poisoning treated with | succimer, EDTA, dimercaprol
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| Acute arsenic poisoning affects mostly | GI
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| Chronic arsenic poisoning affects | everything, carcinogenic
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| Arsenic gas affects mostly | renal system
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| Acute arsenic poisoning treated with | supportive and dimercaprol
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| Chronic arsenic poisoning treated with dimercaprol |
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| Arsenic gas treatment | supportive
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| Acute mercury poisoning causes | SOB, nausea, vomiting
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| Mercuric chloride causes | renal failure, hemorrhagic gastroenteritis
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| Acute mercury tox treated with | succimer, dimercaprol (IM)
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| Chronic mercury poising causes | erethism (behavioral change)
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| Chronic mercury poising treated with | succimer, Unithiol
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| Avoid _ in treating chronic mercury poising | dimercaprol, redistributes to CNS
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| Iron tox symptoms | GI, jaundice, coma
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| Treat Fe tox with | deferoxamine
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| EDTA used for_ detox | Lead
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| Dimercaprol used for | arsenic, mercury and with EDTA for lead
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| Dimercaprol side effects | lipophilic, thrombocytopenia, increased prothrombin time
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| Succimer used for | lead, arsenic ( within a few hours of exposure) and mercury ( within a few hours of exposure)
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| Succimer side effects | less than dimercaprol, liver enzymes, rash, GI
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| Unithiol is a | water soluble dimercaprol
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| Unithiol used for | inorganic mercury or arsenic
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| Penicillamine is used for | copper excess
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| Penicillamine excretion | water soluble, absorbed from GI, excreted unchanged
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| Penicillamine tox | neprhotox, pancytopenia, autoimmune, hemolysis
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| EDTA used for | lead poisoning
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| EDTA administered with | calcium
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| EDTA tox | tubular necrosis and ECG changes
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| Deferoxamine, deferasirox used for | Fe
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| Deferoxamine, deferasirox tox | skin rxn, hepatic and renal dsfx, coagulopathy
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asindhidude
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