Anxiety/Depression
Help!
|
|
||||
|---|---|---|---|---|---|
| Which anxiety disorder is associated with "re-experiencing" a traumatic event and decreased responsiveness or avoidance of current events associated with the trauma | Posttraumatic Stress disorder
🗑
|
||||
| Which type of anxiety disorder displays symptoms of apprehension, worry, irritability, difficulty concentrating, insomnia, and ANS complaints | Generalized Anxiety disorders
🗑
|
||||
| which type of anxiety disorder displays shortlived, recurrent, unpredictable episodes of intense anxiety | Panic Disorder
🗑
|
||||
| how many people who have OCD will develop major depression some time in their lives | 2/3
🗑
|
||||
| Which anxiety disorder includes recurring thought or compulsions that are recongnized as absurd but must be succumbed by the patient to alleviate anxiety | Obsessive compulsive disorder (OCD)
🗑
|
||||
| This disorder may be part of panic disorders and include things like AGORAPHOBIA, SOCIAL PHOBIAS OR SOCIAL ANXIETY DISORDER, PERFORMANCE ANXIETY, ETC. | Phobic Disorder
🗑
|
||||
| What is the general treatment used for Anxiety Disorders | Chronic = daily doses of antidepressants of buspirone
Acute= benzodiazepines for quickest relief
Antidepressants + Benzodiazepine = common
🗑
|
||||
| Which drug is used specifically for anxiety only and is NOT an antidepressant or benzodiazepine | Buspirone (Buspar)
🗑
|
||||
| What is the Mechanism of action of Buspirone (Buspar)? | unknown, but has effect on serotonin like the SSIRs and a slow onset of action
🗑
|
||||
| What is the criteria for diagnosis of clinical depression | symptoms present daily for >2 weeks
🗑
|
||||
| How effective is treatment of depression | 60-70%
🗑
|
||||
| how many people suffer from depression and how many of those seek help | 30% will develop depression sometime in life and only 1/3 will seek help
🗑
|
||||
| What factors are involved in the risk of developing depression | hereditary and situational (social triggers)
🗑
|
||||
| What is believed to be the cause of depression | Unknown, but invovles CNS monoamines norepinephrine, dopamine, and/or serotonin
🗑
|
||||
| What is the treatment for depression | Selected medication based on adverse effects, cost, and past medical history
Drug of Choice: SSRIs or Newer Antidepressants
🗑
|
||||
| How long is medication used to treat depression? | indefinitely for some, but others may be able to taper off meds after 6-12 months of well treated symptoms
🗑
|
||||
| What are the common Serotonin/Norepinephrine Reuptake Inhibitors (S/NRIs) used as antidepressants? | Duloxetine (Cymbalta), Vanlafaxine (Effexor), Desvenlafaxine (Pristiq)
🗑
|
||||
| What are the adverse effects of S/NRIs? | Insomnia, nervousness, dry mouth, anorexia, mild CV effects, sexual dysfunction, sweating, HTN
🗑
|
||||
| What disease is the S/NRI, Duloxetine (cymbalta) FDA approved to treat? | Fibromyalgia
🗑
|
||||
| What patient population is the S/NRI Desvenlafaxine (Pristiq) also effective in treating? | Severe depression and pts. refractory to other agents (diabetic, limb amputee)
🗑
|
||||
| What are the common SSRIs (Selective Serotonin Reuptake Inhibitors | fluoxetine (Prozac), Sertraline (Zoloft), Citalopram (Celexa), Paroxetine (Paxil)
🗑
|
||||
| What is the MoA of the Selective Serotonin Reuptake Inhibitors (SSRIs) | increase concentrations of serotonin and are selective having little effect on norepinephrine or dopamine and low affinity for histaminic, cholinergic, or alpha receptors
🗑
|
||||
| Which Antidepressants have less cardiac side effects and are used most commonly? S/NRIs or SSRIs? | SSRI
🗑
|
||||
| What are the adverse effects of SSRIs | Nausea, insomnia & nervousness, akathisia, sexual dysfunction, serotonin syndrome, physical dependence/withdrawal symptoms
🗑
|
||||
| Which drug is most likely to cause Orthostatic hypotension, sedation, and anticholinergic SEs, SSRIs or TCA's? | TCA's
🗑
|
||||
| What are the symptoms of Serotonin Syndrome | Hypotension, Hypertension, agitation, muscle tightness & twitching, hyperthermia, shivering, tachycardia & other arrhythmias, seizures, coma and death
🗑
|
||||
| What are common Drug Interactions with SSRIs | Serotonin syndrome may aoccure if combining w/ TCAs or MAO-inhibitors or chanign between classes of antidepressants.
liver interactions w/ other drugs
🗑
|
||||
| what are some common therapeutic uses of SSRIs? | Generalized anxiety, phobic disorders, OCD, Premenstrual Dysphoric disorder, bulimia, tourette's syndrom, bipolar, ADHD, neuropathic pain, diabetic peripheral neuropathy pain, post-herpetic neuralgia (shingles pain), migrain prevention
🗑
|
||||
| Which antidepressant is often prescribed to treat insomnia? | Trazodone (Desyrel)
🗑
|
||||
| Whchi Antidepressant is used for smoking cessation and does not cause prblems w/ sedation or sexual dysfunction | Bupropion (wellbutrin, Zyban)
🗑
|
||||
| what are the adverse effects of Bupropion (wellbutrin, Zyban) | dry mouth, weight loss, constipation, HA, insomnia, agitation, and seizure
No problems w/ sedation or sexual dysfunction
🗑
|
||||
| Which Antidepressant causes weight gain and is taken at bedtime due to dedation? | Mirtazepine (Remeron)
🗑
|
||||
| What are the common Monoamine Oxidase Inhibitors (MAO-Is) | Phenelzine (Nardil) & tranylcypromine (Parnate)
🗑
|
||||
| What is the MoA of MAO-Is? | Block MAO-A and MAO-B in liver, intestines, and nerve terminals causing elevated monoamines, norepinephrine, serotonin, and tyramine (MOA-A), and dopamine (MAO-B) In CNS
🗑
|
||||
| What are the adverse effects of MAO-Is? | Orthostatic hypotention, dizziness, sexual dysfunction, sleep disturbance
🗑
|
||||
| What foods cause hypertensive crisis when consumed with MAO-Is? | food containing Tyramine: Cheese, liver, aged or smoked meats, soy sauce, figs, bananas, some imported wines and beers
foods containing vasopressors: chocolate, ginseng, caffeine
🗑
|
||||
| What are common Drug Interactions that may occur with MAO-Is? | Hypertensive Crisis with ephedrine, amphetamines, cocaine, pseudophedrine, TCAs & SSRIs
Serotonin Syndrome with SSRIs and TCAs
Hyperpyrexia with Meperidine or dextromethorphan containing cough suppressants
🗑
|
||||
| How must one d/c Tricyclic Antidepressants (TCAs)? | Do not go off these pills alone!!! They will cause severe rebound HTN
🗑
|
||||
| Do TCA's cause addiction | NO!
🗑
|
||||
| Are TCA's fast acting or slow acting drugs | They take a while to kick in
🗑
|
||||
| What is the most commonly used TCA | Amitriptyline (Elavil)
🗑
|
||||
| What is the MoA of the antidepressants Tricyclic Antidepressants (TCA's) | increase concentration of norepinephrine, dopamine, and serotonin in CNS increase concetrations
🗑
|
||||
| Are TCA's selective to CNS receptors or nonselective? | They are not selective and therefore have an increased number of adverse effects and a narrow therapuetic window
🗑
|
||||
| What are the adverse effects of TCAs? | weight gain, sexual dysfunction, lower seizure thrshold, anticholinergic SE, cariovascular overstimulation, antihistamine SE (Sedatoin/drowsiness), orthostatic hypotention, physical dependence/withdrawls
🗑
|
||||
| What population is at risk for adverse effects with TCAs | elderly men w/ BPH, cardiac disease patients,
🗑
|
||||
| What drug interactions can occur with TCA's | MAO-Is, epinephrine and oral decongestants, anticholinergics like antihistamines, CNS depressants, Potential p-450,
🗑
|
||||
| Do TCA's cause depression? | No, they are a CNS depressant which means they cause sedation, drowsiness, slowed though processes, etc.
🗑
|
||||
| What are other uses of TCAs other than antidepressants | anxiety disorder, phobic disorder, OCD, neuropathic pain, ADHD (same as SSRIs)
🗑
|
||||
| Why do TCA's cause Anticholinergic side effects? | they block Muscarinic receptors
🗑
|
||||
|
🗑
|
Review the information in the table. When you are ready to quiz yourself you can hide individual columns or the entire table. Then you can click on the empty cells to reveal the answer. Try to recall what will be displayed before clicking the empty cell.
To hide a column, click on the column name.
To hide the entire table, click on the "Hide All" button.
You may also shuffle the rows of the table by clicking on the "Shuffle" button.
Or sort by any of the columns using the down arrow next to any column heading.
If you know all the data on any row, you can temporarily remove it by tapping the trash can to the right of the row.
To hide a column, click on the column name.
To hide the entire table, click on the "Hide All" button.
You may also shuffle the rows of the table by clicking on the "Shuffle" button.
Or sort by any of the columns using the down arrow next to any column heading.
If you know all the data on any row, you can temporarily remove it by tapping the trash can to the right of the row.
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.
Normal Size Small Size show me how
Normal Size Small Size show me how
Created by:
aamoore2245
Popular Pharmacology sets