Gastrointestinal Pharmacology
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| Antacid Agents Action | are used to chemically neutralize gastric acid and increase the intragastric pH.
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| Primary antacids are classified as | aluminum-containing, calcium carbonate-containing, magnesium-containing or sodium bicarbonate-containing.
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| Antacid Agents Indications: ) | episodic minor gastric indigestion or heartburn, peptic ulcer, gastroesophageal reflux disease (GERD
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| Antacid Agents Side effects: | acid rebound phenomenon, constipation or diarrhea (depending on the antacid), may effect metabolism of other medications, electrolyte imbalances
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| Antacid Agents Implications for PT: | Since these agents are well tolerated there are typically no side effects that interfere with physical therapy.
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| Patients are more likely to participate in therapy | with effective management of gastrointestinal issues using these agents.
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| Antacid Agents Aluminum-containing: | Antacid Agents Basaljel (aluminum carbonate gel);
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| Antacid Agents Calcium carbonate containing: | Tums (calcium carbonate);
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| Antacid Agents Magnesium-containing: | Milk of Magnesia (magnesium hydroxide);
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| Antacid Agents Sodium bicarbonate-containing: | Antacid Agents Bromo seltzer (sodium bicarbonate)
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| Proton Pump Inhibitor Agents Action: | inhibit the H+/K+ -ATPase enzyme that blocks secretion of acid from gastric cells into the stomach.
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| Proton pump inhibitor agents | agents prevent erosive esophagitis in patients with GERD and acid secretion dysfunction.
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| Proton pump inhibitor agents . | may also possess antibacterial effects against helicobacter pylori (H. pylori) infection
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| Proton Pump Inhibitor Agents Indications: | gastric and duodenal ulcers, GERD, H. pylori
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| Proton Pump Inhibitor Agents Side effects: | increased susceptibility to gastrointestinal infections, headache, diarrhea, abdominal pain,
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| Proton Pump Inhibitor Agents Side effects | gastric polyps, acid rebound with discontinuation of agent
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| Proton Pump Inhibitor Agents Implications for PT: | Since these agents are well tolerated there are typically no side effects that interfere with physical therapy.
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| Proton Pump Inhibitor Agents Implications for PT | Patients are more likely to participate in therapy with effective management of gastrointestinal issues using these agents.
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