Pentose Phosphate Pathway
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show | Hexose monophosphate pathway or 6-phosphogluconate pathway
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Where in the cell does the pentose phosphate pathway occur? | show 🗑
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In which organs does the pentose phosphate pathway take place and what does the created NADPH provide for in each? | show 🗑
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show | An alternative method for glucose metabolism, it does NOT create energy
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show | Pentoses, NADPH, and H+
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Describe the oxidative phase of the pentose phosphate pathway. | show 🗑
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show | Nonoxidative phase = reversible rxns, occur when pentoses arent req'd by cells but glycolytic intermediates are, involves interconversion of sugars resulting in the formation of glycolytic intermediates, enzymes are transketolase (TPP) and transaldolase.
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show | Glucose-6-phosphate -> 6-phosphogluconolactone via G6PD (releasing NADPH and H+), which is then -> 6-phosphogluconate and then-> Ribulose-5-phosphate via 6-phosphogluconate dehydrogenase (releasing NADPH, H+, and CO2)
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What is the regulatory enzyme of the pentose phosphate pathway? | show 🗑
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show | If 3 mols of G6P -> 3 mols of Ribulose5P, Ribulose5P -> Ribose5P (via isomerase) + 2 Xyulose5P (via epimerase) -> 2 mols of F6P and 1 Glyceraldehyde-3P (glycolytic intermediates) via transketolase and transaldolase.
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show | TPP (Thiamine)
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What can be used as a laboratory test to diagnose nutritional thiamine deficiency? | show 🗑
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What is Ribose-5-Phosphate required for? | show 🗑
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show | synthesis of fatty acids, synthesis of steroid hormones, cytochrome p450 system, reduction and detoxification of H2O2, and synthesis of Nitric oxide.
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What does G6PD deficiency lead to? | show 🗑
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What is the significance of reduce glutathione (GSH)? | show 🗑
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show | RBCs because the pentose phosphate pathway is the only means of NADPH generation.
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What precipitating factors lead to G6PD deficiency? | show 🗑
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show | A moderate form of the disease, enough young RBCs have sufficient levels of enzyme so they are normally ok but issues arise when exposed to a precipitating factor.
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Created by:
sprater16