General Anesthetic Drugs
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show | lipid solubility
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show | GABA-A and glycine receptors to GABA and glycine, respectively
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show | acetylcholine (Nicotinic) and serotonin.
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Ketamine and nitrous oxide inhibit ____ activity? | show 🗑
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Partial pressure is? | show 🗑
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Blood/Gas partition coefficient is? | show 🗑
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show | change of the partial pressure (concentration) of the gas in the brain, which is determined by the partial pressure of the gas in arterial blood
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show | with blood/gas partition coeffcient (inverse correlation)
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Halothane has blood/gas coefficient of ___ and a rapidity of onset of___? | show 🗑
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N2O has blood/gas coefficient of ___ and a rapidity of onset of___? | show 🗑
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show | the Minimal Alveolar Concentration that will block movement of 50% of patients in response to incision
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show | MAC
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Lipid/Gas coefficient is related to? | show 🗑
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Blood/gas coefficient is related to? | show 🗑
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show | lipid/gas partition coefficient (low MAC indicates high lipid/gas solubility)
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N20 has MAC of ___ and a lipid/gas coefficient of___? | show 🗑
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Why is N20 considered an "incomplete anesthetic"? | show 🗑
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The therapeutic index for most general anesthetics is? | show 🗑
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show | Provide a smooth and rapid induction of unconsciousness;
Produce amnesia;
Block troublesome reflexes;
Produce skeletal muscle relaxation;
Produce analgesia;
Provide a smooth and rapid emergence and recovery without long lasting adverse effects.
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show | Reduce anxiety, Sedation, Amnesia, “Conscious sedation”
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What is the pre-anesthetic effect of atropine/glycopyrollate (robinul)? | show 🗑
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What is the pre-anesthetic effect of Opioid analgesics? | show 🗑
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show | dose dependent depression of all portions of CNS. Order of sensitivity (most to least) is RAS and cortex > hippocampus > basal ganglia > cerebellum > spinal cord > medulla (irregularly descending anesthesia)
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show | Inhibition of sympathetics;
Stimulation of parasympathetics;
Nausea and vomiting
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What are the general pharmacological effects of anesthetics gases on the cardiovascular system? | show 🗑
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What are the general pharmacological effects of anesthetics gases on the respiratory system? | show 🗑
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show | Altered thermoregulatory control induced hypothermia d/t anesthesia of the hypothalamus and reduced metabolic rate
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Anesthetic gas responsible for developing an induced hepatitis? | show 🗑
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First non-explosive alternative to ether? | show 🗑
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show | isoflurane
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show | enflurane
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show | desflurane
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Anesthetic gas similar to desflurance but less irritating to airway? | show 🗑
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show | ketamine
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What is ketamines MOA? | show 🗑
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show | etomidate
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show | dexmedetomidine (Precedex)
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a carboxylated imidazole | show 🗑
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a substituted isopropylphenol | show 🗑
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IV anesthetic that decreases the rate of dissociation of GABA from its receptors, thereby increasing the duration of GABA-activated opening of chloride channels, with resulting hyperpolarization of cell membranes | show 🗑
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How is propofol cleared? | show 🗑
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show | 1.5 - 2.5 mg/kg IV
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MOA of barbituates? | show 🗑
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show | redistribution and metabolism however large or repeated doses of thiopental may saturate inactive tissue sites resulting in prolonged effects.
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Which is cleared faster: thiopental or etomidate? | show 🗑
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show | ketamine
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What receptor does ketamine NOT interact with? | show 🗑
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T or F: All inhaled anesthetics depress the CV system. | show 🗑
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What drug increases the neuromuscular blocking effects of isoflurane? | show 🗑
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