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General Anesthetic Drugs

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Question
Answer
show lipid solubility  
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show GABA-A and glycine receptors to GABA and glycine, respectively  
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show acetylcholine (Nicotinic) and serotonin.  
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Ketamine and nitrous oxide inhibit ____ activity?   show
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Partial pressure is?   show
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Blood/Gas partition coefficient is?   show
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show change of the partial pressure (concentration) of the gas in the brain, which is determined by the partial pressure of the gas in arterial blood  
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show with blood/gas partition coeffcient (inverse correlation)  
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Halothane has blood/gas coefficient of ___ and a rapidity of onset of___?   show
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N2O has blood/gas coefficient of ___ and a rapidity of onset of___?   show
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show the Minimal Alveolar Concentration that will block movement of 50% of patients in response to incision  
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show MAC  
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Lipid/Gas coefficient is related to?   show
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Blood/gas coefficient is related to?   show
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show lipid/gas partition coefficient (low MAC indicates high lipid/gas solubility)  
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N20 has MAC of ___ and a lipid/gas coefficient of___?   show
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Why is N20 considered an "incomplete anesthetic"?   show
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The therapeutic index for most general anesthetics is?   show
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show Provide a smooth and rapid induction of unconsciousness; Produce amnesia; Block troublesome reflexes; Produce skeletal muscle relaxation; Produce analgesia; Provide a smooth and rapid emergence and recovery without long lasting adverse effects.  
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show Reduce anxiety, Sedation, Amnesia, “Conscious sedation”  
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What is the pre-anesthetic effect of atropine/glycopyrollate (robinul)?   show
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What is the pre-anesthetic effect of Opioid analgesics?   show
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show dose dependent depression of all portions of CNS. Order of sensitivity (most to least) is RAS and cortex > hippocampus > basal ganglia > cerebellum > spinal cord > medulla (irregularly descending anesthesia)  
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show Inhibition of sympathetics; Stimulation of parasympathetics; Nausea and vomiting  
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What are the general pharmacological effects of anesthetics gases on the cardiovascular system?   show
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What are the general pharmacological effects of anesthetics gases on the respiratory system?   show
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show Altered thermoregulatory control induced hypothermia d/t anesthesia of the hypothalamus and reduced metabolic rate  
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Anesthetic gas responsible for developing an induced hepatitis?   show
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First non-explosive alternative to ether?   show
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show isoflurane  
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show enflurane  
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show desflurane  
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Anesthetic gas similar to desflurance but less irritating to airway?   show
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show ketamine  
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What is ketamines MOA?   show
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show etomidate  
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show dexmedetomidine (Precedex)  
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a carboxylated imidazole   show
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a substituted isopropylphenol   show
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IV anesthetic that decreases the rate of dissociation of GABA from its receptors, thereby increasing the duration of GABA-activated opening of chloride channels, with resulting hyperpolarization of cell membranes   show
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How is propofol cleared?   show
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show 1.5 - 2.5 mg/kg IV  
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MOA of barbituates?   show
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show redistribution and metabolism however large or repeated doses of thiopental may saturate inactive tissue sites resulting in prolonged effects.  
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Which is cleared faster: thiopental or etomidate?   show
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show ketamine  
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What receptor does ketamine NOT interact with?   show
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T or F: All inhaled anesthetics depress the CV system.   show
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What drug increases the neuromuscular blocking effects of isoflurane?   show
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