Gout
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| Colchicine | Colcrys
Gloperba
Mitigare
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| Colchicine dosing | two 0.6 mg tablets followed by 1(0.6 mg) tablet in 1 hour
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| Do not exceed how much colchicine in 1 hour | 1.8 mg in 1 hr `
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| When should youstart colchicine | within 36 hours of sympton onset
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| When can you resume prophylaxis after treatment with colchicine | 12 hrs after treatment
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| naproxen | Aleve
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| Indomethacin | indocin
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| Celecoxib | Celebrex
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| How are steriods given | IV, IM, PO, intra-articular or adrencorticotropic hormone
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| Methylpresnisionol | Medrol
Solu-Medrol
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| Methprednisolone dosing | intra-articular if 1-2 large joimts involved
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| Canakinumab | llaris
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| Canakinumab MOA | interleukin 1 anatagonist
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| What must be done prior to canakinumab | TB testing
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| what must be avoided with canakinumab | live vaccines
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| Allopurinol | Zyloprim
Aloprim
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| Allopurinol MOX | Xanthine oxidase inhibitor
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| Febuxostat | Uloric
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| Frbuxostat MOA | Xanthine Oxidase inhibitor
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| Xanthine Oxidase inhibitor | block xanthine oxidase enzyme to decrease uric acid production
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| If taking allopurinol pt should be screened for what gnee | HLA-B 5801 allel
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| UA target level | < 6
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| Probenacid MOA | inhibits reabsorption of UA in the proximal tubule
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| Probenacid is | Uricosuric
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| Pegloticase is | recombinant uricase enzyme
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| Pegloticase MOA | coverts UA to an inactive metabolite allantoin that can be easily excreted
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| Who is pegloticase reserved for | severe refractory gout
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| which xanthine oxidase inhibitor causes increase in LFTs | Febuxostat ( Uloric)
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| Both xanthine oxidase inhibitors have warning for | hepatototoxicity
SKin rash ( TEN, SJS, DRESS)
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| Probenacid can increase the levels of what other drug | beta lactam levels
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| Pegloticase | Krystexxa
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| Pegloticase formulation | IV
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| Krystexxa has boxed warning for | anaphylactic reaction:
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| How to prevent Krystexxa anaphylactic reaction | premedicate with antihistmaine and steroid
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| Pegloticase is contraindicated with | G6PD deficiency
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| which drugs should not be used with febuxostat | Mercaptopurine and azathiopurine
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| Pegloticase should be avoaided with | xanthine oxidase inhibitors and probenacid
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| colchincine side effects | Diarrhea, nausea, myopathy, neuropathy
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| Colchincine should be avoided with | strong CYP34 inhibitor and pgp inhibitors
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