naplex
Help!
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| why is carbidoba given with levidopa? | carbidopa prevents peripheral breakdown for levodopa
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| brand for carbidopa/levodipa | sinemet
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| main ADR of carbidope/levidopa | darkening of urine
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| what is the minium amount of carbidopa needed per day to prevent levodopa breakdown | 70-100mg/day
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| what is the MOA of COMT inhibitor as adjunct in parkinosons | increase the duration of action of levodopa
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| what medications is used as a rescue drug during freezing episodes in parkinsons | apomorphine
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| what skin issue does amantadine cause | livedo reticularis
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| what drugs are mainly used for tremor in parkinsons | anticholinergic: benztropin
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| Alzaheimers diseases is associased with a decrease in what neurotransmitter? | acetycholine
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| what natural products r useful for alzahiemr | vitamin E, ginkgo biloba
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| what is drug treatment for alzahiemr | acetylcholinesterase inhibitors: donepezil for mild and moderate
memantine for moderate to severe
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| brand for donepezil | aricept
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| what is the brand for donepezil+memantine | namzaric
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| how long is the adlarity patch good for? (donepezil) | 7 days
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| how to manage patients are having status epilepticus (seizure for more than 5 minutes) | IV benzo or IM versed or diazepam rectal gel
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| what diet is good to prevent seizures? | ketogenic diet (4:1 ration of fact vs proteins +carbs)
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| which ASM is used for absence seizures | ethosuximide
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| what are some concerns with all ASM? | CNS depression, suicide risk, bone loss, rash
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| moa of valproate? | block sodium channeles and increase GABA
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| Moa of keppra? | inhibit vesicle fusion by binding SV2A protein
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| moa of carbamazepine, phenytoin, topiramata | block sodium channels
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| moa of lamotrigin? | block sodium and decrease glutamate
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| lamotrigine intial dosing for seizures? | 25mg qd
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| main side effects of lamotrigine | hair loss, rash
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| valproate theraputic range | 50-100mcg/ml
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| valpraote ADRS? | hairloss, hyperammonemia, hepatic failure, weight gain
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| carbamazepine theraputic range | 4-12mcg/ml
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| ADRS of carbamazepine? | myelosupression and rash (test for HLA*B 1502), hyponatremia
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| Phenytoin theraputic range? | total 10-20mcg/ml
free 1-2mcg/ml
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| phenytoin max infusion rate> | 50mg/min
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| fosphenytoin max infusion rate? | 150mg PE/min
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| phenobarbital theraputic range? | 20-40mcg/ml
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| which ASM are enzyme inducers? | carbamazepine, phenytoin, phenobarbital
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| which ASM is enzyme inhibitor | valproatek
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| which AMS is preferred in pregnancy | keppra
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