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why is carbidoba given with levidopa?
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brand for carbidopa/levodipa
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neurologic cond
naplex
| Question | Answer |
|---|---|
| why is carbidoba given with levidopa? | carbidopa prevents peripheral breakdown for levodopa |
| brand for carbidopa/levodipa | sinemet |
| main ADR of carbidope/levidopa | darkening of urine |
| what is the minium amount of carbidopa needed per day to prevent levodopa breakdown | 70-100mg/day |
| what is the MOA of COMT inhibitor as adjunct in parkinosons | increase the duration of action of levodopa |
| what medications is used as a rescue drug during freezing episodes in parkinsons | apomorphine |
| what skin issue does amantadine cause | livedo reticularis |
| what drugs are mainly used for tremor in parkinsons | anticholinergic: benztropin |
| Alzaheimers diseases is associased with a decrease in what neurotransmitter? | acetycholine |
| what natural products r useful for alzahiemr | vitamin E, ginkgo biloba |
| what is drug treatment for alzahiemr | acetylcholinesterase inhibitors: donepezil for mild and moderate memantine for moderate to severe |
| brand for donepezil | aricept |
| what is the brand for donepezil+memantine | namzaric |
| how long is the adlarity patch good for? (donepezil) | 7 days |
| how to manage patients are having status epilepticus (seizure for more than 5 minutes) | IV benzo or IM versed or diazepam rectal gel |
| what diet is good to prevent seizures? | ketogenic diet (4:1 ration of fact vs proteins +carbs) |
| which ASM is used for absence seizures | ethosuximide |
| what are some concerns with all ASM? | CNS depression, suicide risk, bone loss, rash |
| moa of valproate? | block sodium channeles and increase GABA |
| Moa of keppra? | inhibit vesicle fusion by binding SV2A protein |
| moa of carbamazepine, phenytoin, topiramata | block sodium channels |
| moa of lamotrigin? | block sodium and decrease glutamate |
| lamotrigine intial dosing for seizures? | 25mg qd |
| main side effects of lamotrigine | hair loss, rash |
| valproate theraputic range | 50-100mcg/ml |
| valpraote ADRS? | hairloss, hyperammonemia, hepatic failure, weight gain |
| carbamazepine theraputic range | 4-12mcg/ml |
| ADRS of carbamazepine? | myelosupression and rash (test for HLA*B 1502), hyponatremia |
| Phenytoin theraputic range? | total 10-20mcg/ml free 1-2mcg/ml |
| phenytoin max infusion rate> | 50mg/min |
| fosphenytoin max infusion rate? | 150mg PE/min |
| phenobarbital theraputic range? | 20-40mcg/ml |
| which ASM are enzyme inducers? | carbamazepine, phenytoin, phenobarbital |
| which ASM is enzyme inhibitor | valproatek |
| which AMS is preferred in pregnancy | keppra |
Created by:
saif1206