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study flashcards for HOSA Pharmacology Knowledge Test

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Term
Definition
Food, Drug, and Cosmetic Act of 1938   A New drug could not be marketed until proven safe, tested for toxicity, and required adverse drug effects to be reported.  
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Kefauver-Harris Amendment (1962)   Requires proof of safety and efficacy of a drug for approval before marketing  
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Drug Listing Act of 1972   Drugs must have a National Drug Code number.  
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Drug Regulation and Reform Act of 1978   Quicker development and distribution of new drugs  
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Anabolic Steroid Control Act of 1990   Placed all into category III drugs (CSA)  
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Prescription Drug Amendments of 1992   Allowed rapid approval of drugs for life-threatening diseases  
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Food and Drug Administration Modernization Act of 1997   Allowed rapid approval of drugs by the FDA  
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Plasma Binding   When proteins bind to drugs and the decrease the amount of free-flowing drug in the bloodstream allowing the drug to stay in the body for longer.  
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Benzodiazepines   Category 4 meds  
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Benign Tumor   Localized, is smooth and freely movable, and do not break the skin  
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What is another name for antineoplastic agents?   Chemotherapeutic agents  
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What is an anticonvulsant?   A drug used to treat seizures, neuropathic pain, Bipolar disorder, and anxiety disorder  
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How do anticonvulsants work?   By depressing abnormal nerve impulse discharges in the CNS. (central nervous system) A person taking oral contraceptive should not take anticonvulsants.  
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Anticonvulsant   Diazepam  
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Which name (trade or generic) starts with a lowercase letter?   Generic  
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What are the 5 stages of the cell cycle?   G1, S, G2, M, G0  
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Select the option that shows the cell kill theory.   90% of 100% Killed, 10% left, 90% of 10% Killed, 1% left Body attacks rest of the cancer  
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Gemcitabine   Used For: Solid tumors: pancreatic, NSCLC  
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Nelarabines   C11H15N5O5  
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Platinum-based drugs   Cisplatin, oxaliplatin, carboplatin  
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What drug has the chemical formula of C16H20FN3O4?   Linezolid  
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What is one example of a Topical Anti inflammatory or Corticosteroid Agent?   Hydrocortisone  
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Pharmacodynamics   The branch of pharmacology concerned with the effects of drugs and the mechanism of their action.  
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Pharmacology   The branch of medicine concerned with the uses, effects, and modes of action of drugs.  
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Pharmacokinetics   The branch of pharmacology concerned with the movement of drugs within the body.  
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Pharmacotherapeutics   A branch of Pharmacology, which is defined by Merriam-Webster as "the study of the therapeutic uses and effects of drugs" this is a study of beneficial and adverse effects of drugs.  
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Potentiation   The increase in strength of nerve impulses along pathways that have been used previously, either short-term or long-term.  
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Recombinant DNA technology   Segments of two or more different DNA molecules.  
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Safe drug   A drug that causes no harmful effects when taken in high doses over a long period of time.  
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Distribution   Is a branch of pharmacokinetics which describes the reversible transfer of a drug from one location to another within the body.  
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Drug blood level   The concentration of drug and/or its active metabolite(s) or chemical present in the blood (serum or plasma); amount of drug present in blood.  
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Drug half   When 0.5 concentration or amount of drug in the body reduced.  
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Drug interaction   Affects the activity of a drugs when both are administered together.  
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Excretion   Any one of a number of processes by which a drug is eliminated (that is, cleared and excreted) from an organism either in an unaltered form (unbound molecules) or modified as a metabolite.  
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First pass   Metabolism of a drug before it reaches the systemic circulation or through absorption.  
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Glycoside   A sugar is bound to another functional group  
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Habituation   Tolerance to the effects of a drug acquired through continued use.  
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Hypersensitivity reaction   An immune-mediated reaction to a drug.  
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Ideal drug   Effective and safe, producing no side effects or adverse reactions  
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Antagonist   Medication that binds to a receptor  
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Allergic Reaction   Hypersensitivity to a drug  
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Denominator   Part of a fraction representing the total number of parts  
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Dosage strength   Amount of drug in the given form, such as tablet or capsule  
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Adverse reaction   Undesirable drug effect.  
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Dimensional analysis   Newer method of calculating drug dosages based on fractions metric system. System of measurement based on units of 10.  
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Numerator   Part of a fraction representing the number of parts taken (the number above the line).  
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Solvent   Fluid in which a solid dissolves; also called the diluent.  
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Antagonism   Cancellation or reduction of one drug's effect by another drug  
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Nonprescription Drugs   Safe when taken as directed, can be obtained without a prescription.  
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What is a common adverse reaction to chemotherapy drugs?   Hair loss  
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In what drug schedule would you find heroin and other specialty drugs?   Schedule 1  
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Pure Food and Drug Act (1906)   Forbade the manufacture, sale, and transportation of adulterated or mislabeled foods and drugs.  
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Shirley Amendment of 1912   Prevented fraudulent therapeutic claims by drug manufacturers  
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Harrison Act of 1914   Established the word narcotic and required the use of a stamp on narcotic drug containers. Also regulated the importation, manufacture, sale, and use of opium, codeine, and their derivatives.  
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Durham-Humphrey Amendment (1951)   Replaced Laws of 1938. Required designation of whether or not the drug was prescription or OTC  
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Schedule I   This type of drug has no accepted medical use in the United States and has a high potential for abuse  
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Schedule II drugs   Accepted for medical use but with severe restrictions (high potential for abuse)  
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Schedule III drugs   Have low potential for abuse with an accepted medical use. Prescription only  
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Schedule IV   Abuse potential exists, but less than Sch III. Examples are: Ambien, Darvocet and Lorazepam.  
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Schedule V drugs   Lowest potential for abuse. May be sold OTC to people that show ID  
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Controlled Substances Act (1970)   Replaced all laws passed prior to it concerning drug control. 5 drug schedules put in place based on potential for abuse.  
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Poison Prevention Packaging Act (1970)   Implemented child resistant packaging  
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Orphan Drug Act of 1983   Established funding for research of rare chronic illnesses for new and old drugs.  
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Drug Price Competition and Patent Term Restoration Act of 1984   Eased requirements for marketing generic drugs  
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Omnibus Budget Reconciliation Act (OBRA 1990)   Mandated that OTC drugs be documented  
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Examples of Sulfonamides   Sulfamethoxazole, sulfisoxazole, sulfadiazine  
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Uses for Sulfonamides   Treating UTIs, Ulcerative colitis, 2nd and 3rd degree burns  
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Drugs that interact with Sulfonamides   Oral anticoagulants, methotrexate, and hydantoins  
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What are the 4 groups of penicillin?   Natural penicillins, penicillinase-resistant penicillins, aminopenicillins, extended-spectrum penicillins  
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Uses for Penicillins   UTIs, Septicemia, Meningitis, Intra-Abdominal infections, Sexually Transmitted Infections (syphilis), Pneumonia and other respiratory infections  
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What variables can effect drug dosage?   Weight, Age, Height, Gender, Genetics, Diet  
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Another name for antianxiety drugs   Anxiolytics  
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3 Examples of antianxiety drugs   Alprazolam, Doxepin, Lorazepam  
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Acronym for cancer in adults?   CAUTION  
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What are the common signs of childhood cancer and the abbreviation? (CHILD CANCER) Part 1   C ontinued unexplained weight loss H eadaches, often with early morning vomiting I ncreased swelling or persistant pain in bones, joints, back, or legs  
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What are the common signs of childhood cancer and the abbreviation? (CHILD CANCER) Part 2   L ump or mass, especially in the abdomen, neck, chest, pelvis, or armpits D evelopment of excessive bruising, bleeding, or rash  
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What are the common signs of childhood cancer and the abbreviation? (CHILD CANCER) Part 3   C onstant infection A whitish color behind the pupil N ausea that that persists or vomiting without nausea  
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What are the common signs of childhood cancer and the abbreviation? (CHILD CANCER) Part 4   C onstant tiredness or noticeable paleness E ye or vision changes that occur suddenly and persist R ecurrent and persistent fevers of unknown origin  
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What chemotherapy targets?   Fast-dividing cells  
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What is the difference between stage and grade in cancer diagnosis?   Stage is how invasive a tumor is, grade is used to classify how abnormal a cancer cell looks under a microscope  
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Malignant Tumor   A tumor that metastasizes to different parts of the body through the lymph nodes and blood vessels  
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Poly-Pharmacy   The simultaneous use of multiple drugs to treat a single ailment or condition.  
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Receptor site   A molecular site or the docking port on the surface of, or within, a cell, usually involving proteins that are capable of recognizing and binding with specific molecules; supplement.  
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Replacement therapy   Treatment aimed at making up a deficit of a substance normally present in the body.  
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Solubility   Ability of particles to be dissolved.  
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Unbound Drug   A drug is kept in the bloodstream  
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Idiosyncratic   An unexpected, unusual response to a Drug.  
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Indication   Reason to use a particular drug for a particular disorder.  
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Alkaloid   A drug that is combined with acids to make salts  
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Anti-Inflammatory Drug   A drug that reduces inflammation  
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Biotransformation   Chemical changes that a substance undergoes in the body  
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Curative   Medication prescribed to kill the causative agents  
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Demulcent   Drug used to soothe a body part or to relieve symptoms of irritation  
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Gram   Mass metric measure equivalent to one thousandth of a kilogram  
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Liter   Metric measure of volume, roughly equivalent to quart in household measure  
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Prescription Drugs   Potentially harmful unless their use is supervised by a licensed health care provider, such as a nurse practitioner, physician, or dentist.  
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