Mechanism of action for the major categories of antihypertensives
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| ACE inhibitors (captopril, enalapril) | show 🗑
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| Angiotensin antagonists (losartan and EXP3174) | show 🗑
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| show | Block Ca++ channels. Decreased intracellular Ca++ leads to reduced contractility and vasodilatation.
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| α1-antagonists (prazosin, doxazocin) | show 🗑
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| show | Decomposes to NO, which activate guanylyl cyclase, thus increasing cGMP levels, and causing vasodilatation
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| show | Reduction of blood volume/indirect vasodilatation
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| show | α2-agonists. False transmitter activates central inhibitory neurons, causing inhibition of NA release and vasodilatation.
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| show | Block β1-receptors in heart, causing decreased rate, systolic BP, cardiac contractility, and myocardial O2 demand. Work in heart, kidney (RAS), and CNS
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