Gundrum Day 1
Quiz yourself by thinking what should be in
each of the black spaces below before clicking
on it to display the answer.
Help!
|
|
||||
|---|---|---|---|---|---|
| Trastuzumab dosing | Weight based
🗑
|
||||
| Carboplatin dosing | Calvert Formula
🗑
|
||||
| Methotrexate | Antifolate, Antimetabolite
🗑
|
||||
| Pemetrexed | Antifolate, Antimetabolite
🗑
|
||||
| 5-Fluoruracil | Antipyrimidine, Antimetabolite
🗑
|
||||
| Capecitabine | Antipyrimidine, Antimetabolite
🗑
|
||||
| Cytaraine | Antipyrimidine, Antimetabolite
🗑
|
||||
| Gemcitabine | Antipyrimidine, Antimetabolite
🗑
|
||||
| 6-MP | Antipurine, Antimetabolite
🗑
|
||||
| Fludarabine | Antipurine, Antimetabolite
🗑
|
||||
| Cladribine | Antipurine, Antimetabolite
🗑
|
||||
| Clofarabine | Antipurine, Antimetabolite
🗑
|
||||
| Hydroxyurea | Antimetabolite
🗑
|
||||
| Vincristine | Vinca Alkaloid, Antimicrotubule
🗑
|
||||
| Vinblastine | Vinca Alkaloid, Antimicrotubule
🗑
|
||||
| Vinorelbine | Vinca Alkaloid, Antimicrotubule
🗑
|
||||
| Paclitaxel | Taxane, Anitmicrotubule
🗑
|
||||
| Docetaxel | Taxane, Antimicrotubule
🗑
|
||||
| Irinotecan | Camptothecan, Topoisomerase I inhibitor
🗑
|
||||
| Topotecan | Camptothecan, Topoisomerase I inhibitor
🗑
|
||||
| Etoposide | Epipodophyllotoxin, Topoisomerase II Inhibitor
🗑
|
||||
| Cell Cycle Specific Classes | Antimetabolites, Antimicrotubules, Topoisomerase I Inhibitors, Topoisomerase II Inhibitors, Hormonal Agents, mTORs
🗑
|
||||
| Antimetabolite subclasses | Antifolates, Antipyrimidines, Antipurines,
🗑
|
||||
| Antimicrotubule subclasses | Vinca Alkaloids, Taxanes
🗑
|
||||
| Topoisomerase I Inhibitor Subclasses | Camptothecans
🗑
|
||||
| Topoisomerase II Inhibitor Subclasses | Epipodophyllotoxin
🗑
|
||||
| Hormonal Agents subclasses | SERMS, Aromatase Inhibitors, LHRH agonists, Antiandrogens
🗑
|
||||
| Tamoxifen | SERM, Hormonal Agent
🗑
|
||||
| Raloxifene | SERM, Hormonal Agent
🗑
|
||||
| Letrozole | Aromatase Inhibitor, Hormonal Agent
🗑
|
||||
| Anastrazole | Aromatase Inhibitor, Hormonal Agent
🗑
|
||||
| Exemestane | Aromatase Inhibitor, Hormonal Agent
🗑
|
||||
| Everolimus | mTOR inhibitor
🗑
|
||||
| Temsirolimus | mTOR inhibitor
🗑
|
||||
| Blemoycin | Cell cycle specific
🗑
|
||||
| L-asparaginase | Cell cycle specific
🗑
|
||||
| Peg-asparagase | Cell cycle specific
🗑
|
||||
| Erwinia asparaginase | Cell cycle specific
🗑
|
||||
| Cell Cycle non-specific Classes | Alkylating agents, anthracyclines, tyrosine kinase inhibitors, monoclonal antibodies, hormonal agents, immunomodulators, proteasome inhibitors
🗑
|
||||
| Alkylating Agent Subclasses | Nitrogen Mustard, Platinums
🗑
|
||||
| Chlorambucil | Nitrogen Mustard, Alkylating agent
🗑
|
||||
| Cyclophosphamide | Nitrogen Mustard, Alkylating agent
🗑
|
||||
| Ifosfamide | Nitrogen Mustard, Alkylating agent
🗑
|
||||
| Cisplatain | Platinum, Alkylating agent
🗑
|
||||
| Carboplatin | Platinum, Alkylating agent
🗑
|
||||
| Oxaliplatin | Platinum, Alkylating agent
🗑
|
||||
| Daunorubicin | Anthracycline
🗑
|
||||
| Doxorubicin | Anthracycline
🗑
|
||||
| Idarubicin | Anthracycline
🗑
|
||||
| Epirubicin | Anthracycline
🗑
|
||||
| Imatinib | Tyrosine Kinase Inhbitor
🗑
|
||||
| Dasatinib | Tyrosine Kinase Inhbitor
🗑
|
||||
| Nilotinib | Tyrosine Kinase Inhbitor
🗑
|
||||
| Bosutinib | Tyrosine Kinase Inhbitor
🗑
|
||||
| Erlotinib | Tyrosine Kinase Inhbitor
🗑
|
||||
| Rituximab | Monoclonal Antibody
🗑
|
||||
| Bevacizumab | Monoclonal Antibody
🗑
|
||||
| Cetuximab | Monoclonal Antibody
🗑
|
||||
| Trastuzumab | Monoclonal Antibody
🗑
|
||||
| Leuprolide | LHRH agonist, hormonal agent
🗑
|
||||
| Goserelin | LHRH agonist, hormonal agent
🗑
|
||||
| Bicalutamide | Antiandrogen, hormonal agent
🗑
|
||||
| Flutamide | Antiandrogen, hormonal agent
🗑
|
||||
| Nilutamide | Antiandrogen, hormonal agent
🗑
|
||||
| Thalidomide | Immunomodulator
🗑
|
||||
| Lenalidomide | Immunomodulator
🗑
|
||||
| Bortezomib | Proteasome Inhibitor
🗑
|
||||
| Carfilzomib | Proteasome Inhibitor
🗑
|
||||
| -trex- | Antifolates
🗑
|
||||
| -bine | antipyrimidine, antipuriness (excet 5-FU, 6-MP)
🗑
|
||||
| Vin- | Vinca Alkaolid
🗑
|
||||
| -taxel | taxanes
🗑
|
||||
| -otecan | Topoisomerase I inhibitors
🗑
|
||||
| -oposide | topoisomerase II Inhibitors
🗑
|
||||
| -fen- | SERMS
🗑
|
||||
| -ozole | Aromatase Inhibitors (except Exemastane)
🗑
|
||||
| -olimus | mTOR Inhibitors
🗑
|
||||
| -platain | platinums
🗑
|
||||
| -rubicin | anthracyclines
🗑
|
||||
| -tinib | Tyronse kinase inhbitors
🗑
|
||||
| -mab | monoclonal antibodies
🗑
|
||||
| -amide | antiandrogens
🗑
|
||||
| -lidomide | immunomodulators
🗑
|
||||
| -zomib | proteaseome inhibitors
🗑
|
||||
| antimetabolites MOA | similar in structure to nucleotides, disrupts the replication of DNA, RNA and nucleic acids; S phase
🗑
|
||||
| Antifolates MOA | inhibits DHFR, S phase
🗑
|
||||
| Methotrexate DIs | NSAIDS, PPIs, Penicillins
🗑
|
||||
| Methotrexate Clinical pearls | -high dose MTX requires leucovorin resucue + NaHCO3 to maintain urine pH > 7
🗑
|
||||
| Pemetrexed Clinical pearls | -supplement with folic acid 400 mcg PO daily and vitamin B 12 1000 mcg IM every 9 weeks to prevent myelosuppression
-premedicate with dexamethasone 4 mg PO BID the day before, day of and day after treatment fo avoid rash
🗑
|
||||
| Leucovorin Indications | -folate rescue with high dose methotrexate
-stabilizes FdUMP binding when used with 5-Fluorouracil
🗑
|
||||
| 5-Fluorouracil MOA: continuous infusion | FdUMP binds to/inactivates thymidylate synthase
🗑
|
||||
| 5-Fluorouracil MOA: Bolus | Incorporates into DNA /RNA as a flase nucleotides and interferes with function
🗑
|
||||
| 5-Fluorouracil Drug interactions | Strong CYP2C9 inhibitor- increased warfarin effect
🗑
|
||||
| Cytarabine MOA | inhibits DNA polymerase (inhibits DNA elongation)
🗑
|
||||
| Cytarabine Adverse Effects | High-dose = cellbeullar toxicity, conjunctivitis
🗑
|
||||
| Cytarabine Clinical pearls | -corticosteroids may help with flu-like symptoms
-steroids eye drops should be administered during high-dose administration to avoid conjunctivitis
🗑
|
||||
| Gemcitabine MOA | inhibits DNA polymerase (inhibits DNA elongation), Inhibits DNA synthesis/repair
🗑
|
||||
| Gemcitabine Clinical pearls | -rash may respond to topical steroids, fevers may respond to acetaminophen
🗑
|
||||
| Purines MOA | incorporates into DNA as a false purine and stops DNA synthesis
🗑
|
||||
| 6-MP drug interactions | allopurinol increases toxicity, 6-MP reduces anticoagulant effects of warfarin
🗑
|
||||
| Fludarabine Adverse effects | tumor lysis syndrome, pulmonary toxicity, peripheral neuropathis, altered mental status
🗑
|
||||
| Fludarabine Clinical pearls | Prophylaxis required for PCP and HSV infections
🗑
|
||||
| Cladribine Clinical pearls | requires prophylaxis against PCP
🗑
|
||||
| Clofarabine adverse effects | elevated LFTs, nausea/vomiting, tumor lysis syndrome
🗑
|
||||
| Hydroxyurea Clinical pearls | Can be used to decreased WBC counts rapidly to prevent adverse effects of leukocyotosis
🗑
|
||||
| Vinca Alkaloids MOA | Destabilize microtubule assembly, M phase
🗑
|
||||
| Taxanes MOA | Stabilize microtubule assembly, M phase
🗑
|
||||
| Vincristine DLT | Peripheral neuropathies, constipation
🗑
|
||||
| Vinca Alkaloids Clinical Pearls | lethal if administered intrathecally
🗑
|
||||
| Paclitaxel Clinical Pearls | Contains CREMOPHOR which leads to hypersensitivity reactions. Pre-medicate with dexamethasone, diphenhydramine and ranitidine to decrease hypersensitivity reactions
🗑
|
||||
| Docetaxel clinical Pearls | Contains POLYSORBATE 80 (less hypersensitivity); Give Dexamethasone day before, day of and day after administration to decrease fluid retention
🗑
|
||||
| Topoisomerase I inhibitors MOA | active during the S phase, single strand breaks
🗑
|
||||
| Topoisomerase II Inhibitors MOA | active during the G2 phase, double strand breaks
🗑
|
||||
| Irinotecan DLT | diarrhea
🗑
|
||||
| Acute diarrhea | <12 hours after administration, treated with atropine
🗑
|
||||
| Delayed diarrhea | >12 hours after administration, treated with loperamide
🗑
|
||||
| Active metabolize of irinoteccan | SN-38
🗑
|
||||
| Etoposide Adverse Effects | secondary malignancies
🗑
|
||||
| Bleomycin DLT | pulmonary toxicity, requires pulmonary function test
🗑
|
||||
| L-asparaginase, Peg-asparagase and Erwinia asparaginase ADRs | Pancreatitis
🗑
|
||||
| Peg-asparagase is derived from | E Coli
🗑
|
||||
| Erwinia asparaginase is derived from | Erwinia Chrysanthemi
🗑
|
||||
| Chlorambucil ADRs | secondary malignancies
🗑
|
||||
| Cyclophosphamide ADRs | hemorrhagic cystitis
🗑
|
||||
| Cyclophosphamide Clinical Pearls | -Hydration needed to prevent hemorrhagic cystitis
-Mesna may be requried with high-dose regimens
🗑
|
||||
| Ifosfamide ADR | hemorrhagic cystitis
🗑
|
||||
| Ifosfamide Clinial Pearls | -Hydration needed to prevent hemorrhagic cystitis
-Mesna always given to prevent hemorrhagic cystitis
-methylene blue may be given for CNS toxicities
🗑
|
||||
| Cisplatin Clinical Pears | Highly emetogenic
🗑
|
||||
| Calavert Formula | Dose (mg) = Target AUC x (CrCl + 25)
🗑
|
||||
| Oxaliplatin DLT | peripheral neuropathies exacerbated by cold
🗑
|
||||
| Anthracyclines ADRs | cardiac toxicity, LVEF monitoring, maximum lifetime doses
🗑
|
||||
| mAb soure: -o- | Murine, 100% mouse
🗑
|
||||
| mAb soure: -xi- | chimeric 67% human
🗑
|
||||
| mAb soure: -zu- | humanized 90% human
🗑
|
||||
| mAb soure: -u- | human 100% human
🗑
|
||||
| monoclonal antibodies DLT | infusion-related reactions
🗑
|
||||
| Rituximab Clinical Pears | -reactivation of hep B can occur
-Premedicate with APAP and diphenhydramine
🗑
|
||||
| Trastuzumab ADRS | Cardiac toxicity, dosed as mg/kg
🗑
|
||||
| Cetuximab MOA | binds to epidermal growth factor receptor-1, premedicate with diphenhydramate
🗑
|
||||
| Cetiximab ADR | Rash
🗑
|
||||
| Bevacizumab MOA | Binds to VGEF ligand
🗑
|
||||
| Tyrosine Kinase Inhibitors MOA | inhibits BCR-ABL tyrosine kinase
🗑
|
||||
| Imatinib ADRs | -CHF
🗑
|
||||
| Nilotinib counseling points | -take twice daily, hyperglycemia
🗑
|
||||
| mTOR MOA | targets mTOR, which is a molecule that is required for multiple interacellular signaling pathways, G1 phase
🗑
|
||||
| Temsirolimus Clinical Pearls | requires diphenhydramine pemedication
🗑
|
||||
| Bortezomib MOA | Reversible inhibition of 26S proteasome, leading to accumulation of cellular debris
🗑
|
||||
| Carfilzomib MOA | Irreversible inhibition of 20s proteasome, leading to accumulation of cellular debris
🗑
|
||||
| DLT: Diarrhea, hand-foot syndrome, mucositis | Continuous infusion 5-FU, Capectabine
🗑
|
||||
| DLT: peripheral neuropathies, constipation | Vincristine
🗑
|
||||
| DLT: diarrhea | Irinotecan
🗑
|
||||
| DLT: pulmonary toxicitiy | Bleomycin
🗑
|
||||
| DLT: hypersensitivity reations | Asparaginase
🗑
|
||||
| DLT: N/V | Cisplatin
🗑
|
||||
| DLT: Peripheral neuropathies exacerbated by cold | Oxaliplatin
🗑
|
||||
| DLT: Infusion-related reactions | Monocolonal antibodies
🗑
|
||||
| DLT: peripheral neuropathies, myelosuppression | Bortezomib, Cafilzomib
🗑
|
||||
| Rifampin | CYP3A4 inducer
🗑
|
||||
| CBZ | CYPEA4 inducer
🗑
|
||||
| phenytoin | CYP3A4 inducer
🗑
|
||||
| phenobarbital | CYP3A4 inducer
🗑
|
||||
| St. John's Wort | CYP3A4 inducer
🗑
|
||||
| Azole Antifungals | CYP3A4 inhbitor
🗑
|
||||
| Calcium Channel Blockers | CYP3A4 inhbitor
🗑
|
||||
| Amiodarone | CYP3A4 inhbitor
🗑
|
||||
| SSRIs | CYP3A4 inhbitor
🗑
|
||||
| Cyclosporine | CYP3A4 inhbitor
🗑
|
||||
| Tacrolimus | CYP3A4 inhbitor
🗑
|
||||
| Aprepitant | CYP3A4 inhbitor
🗑
|
||||
| Grapefruit | CYP3A4 inhbitor
🗑
|
||||
| Asparaginase Cell Cycle | G1
🗑
|
||||
| Bleomycin Cell Cycle | G2
🗑
|
Review the information in the table. When you are ready to quiz yourself you can hide individual columns or the entire table. Then you can click on the empty cells to reveal the answer. Try to recall what will be displayed before clicking the empty cell.
To hide a column, click on the column name.
To hide the entire table, click on the "Hide All" button.
You may also shuffle the rows of the table by clicking on the "Shuffle" button.
Or sort by any of the columns using the down arrow next to any column heading.
If you know all the data on any row, you can temporarily remove it by tapping the trash can to the right of the row.
To hide a column, click on the column name.
To hide the entire table, click on the "Hide All" button.
You may also shuffle the rows of the table by clicking on the "Shuffle" button.
Or sort by any of the columns using the down arrow next to any column heading.
If you know all the data on any row, you can temporarily remove it by tapping the trash can to the right of the row.
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.
Normal Size Small Size show me how
Normal Size Small Size show me how
Created by:
Bmiller01
Popular Pharmacology sets