Pharm Chp20
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| Define analgesia | is inhibition of the perception of pain or a condition in which the body is receiving painful stimulation, but the brain does not interpret the stimulation as pain.
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| Explain the term inflammation | a condition in which tissue have been damaged, characterized by swelling, pain, heat, and sometimes redness.
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| Joint pain | Arthralgia
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| Pain associated with muscle injury | Myalgia
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| Inflammation of joints | Arthritis
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| Small area of skin or mucous membrane that is discolored because of localized hemorrhages. | Petechia
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| Condition in which pain and inflammation of joints are accompanied by elevated body temperature | Rheumatic fever
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| Painful menstruation | Dysmenorrhea
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| Condition in which toxic doses of salicylates result in nausea, tinnitus and delirium. | Salicylism
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| What are the three major pharmacological effects produced by the Salicylates? | The three A’s associated with the pharmacological action of the salicylates are antipyresis, analgesia, and anti-inflammatory effects.
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| How do the non-opioid analgesics relieve pain? | Non-opiod analgesic inhibits the synthesis of prostaglandins and bradykinins, which are produced in response to an acute injury or chronic insult to tissue
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| Why do some people experience nausea and vomiting after taking aspirin? | Salicylates directly irritate the stomach mucosal lining
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| how do anti-inflammatory drugs interrupt the process of inflammation? | Drugs that reduce the inflammatory response stabilize cell membrane so that edema is lessened.
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| which anti-inflammatory drugs should not be administrated over long period of time? | , the acute treatment period with drugs such as indomethacin or naproxen is often limited because of the potential for intense gastric irritation.
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| Which of the following is pharmacologically considered an all around anti-inflammatory drug? | Ibuprophen
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| Cyclooxygenase (COX) is a family of enzymes that? | make various prostaglandins from arachidonic acid
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| Which of the following is correct about NSAIDS? | they are large class of anti-inflammatory drugs that inhibit more than one type of cycloocygenase (COX-1, 2)
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| Acetaminophen | is an aspirin substitute for analgesia and anitpyresis in aspirin sensitive patients
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| NSAIDS are | highly bound to plasma proteins
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| Which of the following is correct? | uriocsuric drugs can be given with hypouricmic drugs to lower uric acid concentrations
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| The COX-2 selective NSAIDS celecoxib (Celebrex) | is primarily an anti-inflammatory drug
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| Anti-inflammatory drugs. | vary in their ability to reduce all types of inflammation
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| Select all of the following that are part of the inflammatory process. | prostaglandins are released, Phagoctyes migrate to area,Vasodilation, proteins leak out of injured cells
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| Under which circumstances would non-opioid drugs be the appropriate treatment? | for acute postoperative pain
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| Which of the following is not a reason to choose acetaminophen? | for low GI irritation
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| Choose the reason why Prohenecid is useful in treating gout | enhances the renal excretion of uric acid
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| Select the indications for aspirin | analgesia, antipyresis, Anticoagulation
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| Gout Treatment | Allopurinol, Colchicine, Febuxostat, probenecid
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| Non-steroidal anti-inflammatory | Etodolac, Ibuprofen, Indomethacin, Naproxen
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